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GENE INFORMATION

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Gene name

PTP4A3 (HGNC Symbol)

Synonyms

PRL-3, PRL-R, PRL3

Description

protein tyrosine phosphatase type IVA, member 3 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist. [provided by RefSeq, Jul 2008]

Chromosome

8 (Chromosome progress)

Cytoband

q24.3

Chromosome location (bp)

142402093 - 142441620

Ensembl

ENSG00000184489 (version 69.37)

Entrez gene

11156

UniProt

O75365

neXtProt

NX_O75365

Antibodypedia

PTP4A3 antibodies
 

PROTEIN VIEW

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PTP4A3-001
 
PTP4A3-002
 
PTP4A3-003
 
PTP4A3-004
 
PTP4A3-201
 
PTP4A3-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTP4A3-001 ENSP00000428976
ENST00000521578
O75365
Show all »
Show » Show » 173 19.5 No 0
PTP4A3-002 ENSP00000428758
ENST00000520105
O75365
Show all »
Show » Show » 148 16.8 No 0
PTP4A3-003 ENSP00000430332
ENST00000524028
E5RFQ4
Show all »
87 10.4 No 0
PTP4A3-004 ENSP00000428725
ENST00000523147
E5RGR3
Show all »
70 8 No 0
PTP4A3-201 ENSP00000332274
ENST00000329397
O75365
Show all »
Show » Show » 173 19.5 No 0
PTP4A3-202 ENSP00000331730
ENST00000349124
O75365
Show all »
Show » Show » 148 16.8 No 0