DUSP8

GENERAL INFORMATION

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Gene name

DUSP8

Gene description

Dual specificity phosphatase 8

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (cerebral cortex)
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Glial cells displayed strong cytoplasmic immunoreactivity, while endothelial cells were distinctly stained. Cells of the male genital tract showed moderate immunoreactivity. Most other normal tissues were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA020071
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (cerebral cortex)

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

DUSP8 (HGNC Symbol)

Synonyms

C11orf81, FLJ42958, HB5, HVH-5

Description

Dual specificity phosphatase 8 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

p15.5

Chromosome location (bp)

1554044 - 1571920

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000184545 (version 78.38)

Entrez gene

1850

UniProt

Q13202 (UniProt - Evidence at protein level)

neXtProt

NX_Q13202

Antibodypedia

DUSP8 antibodies


PROTEIN BROWSER

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ENST00000331588
 
ENST00000397374
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DUSP8-001 ENSP00000380530
ENST00000397374
Q13202
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Show » Show » 625 65.8 No 0
DUSP8-201 ENSP00000329539
ENST00000331588
Q13202
Show all »
Show » Show » 625 65.8 No 0