DUSP8

GENE INFORMATION

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Gene name

DUSP8 (HGNC Symbol)

Synonyms

C11orf81, FLJ42958, HB5, HVH-5

Description

dual specificity phosphatase 8 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

p15.5

Chromosome location (bp)

1575274 - 1593150

Ensembl

ENSG00000184545 (version 73.37)

Entrez gene

1850

UniProt

Q13202 (UniProt - Evidence at transcript level)

neXtProt

NX_Q13202

Antibodypedia

DUSP8 antibodies
 

PROTEIN VIEW

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DUSP8-001
 
DUSP8-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DUSP8-001 ENSP00000380530
ENST00000397374
Q13202
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Show » Show » 625 65.8 No 0
DUSP8-201 ENSP00000329539
ENST00000331588
Q13202
Show all »
Show » Show » 625 65.8 No 0