SOCS3

GENERAL INFORMATION

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Gene name

SOCS3

Gene description

Suppressor of cytokine signaling 3

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues displayed weak to moderate cytoplasmic positivity. Membranous positivity was observed in a few cases. Hepatocytes and lymphoid tissues were negative. Distinct immunoreactivity was observed in gall bladder, distal tubules of the kidney and in fallopian tube.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB012220
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

SOCS3 (HGNC Symbol)

Synonyms

CIS3, Cish3, SOCS-3, SSI-3

Description

Suppressor of cytokine signaling 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q25.3

Chromosome location (bp)

78356778 - 78360077

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000184557 (version 78.38)

Entrez gene

9021

UniProt

O14543 (UniProt - Evidence at protein level)

neXtProt

NX_O14543

Antibodypedia

SOCS3 antibodies


PROTEIN BROWSER

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ENST00000330871
 
ENST00000587578
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SOCS3-001 ENSP00000330341
ENST00000330871
O14543
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Show » Show » 225 24.8 No 0
SOCS3-002 ENSP00000464727
ENST00000587578
Show » 16 1.7 No 0