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GENE INFORMATION

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Gene name

PDE4B (HGNC Symbol)

Synonyms

DPDE4

Description

phosphodiesterase 4B, cAMP-specific (HGNC Symbol)

Entrez gene summary

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

p31.3

Chromosome location (bp)

66258197 - 66840259

Ensembl

ENSG00000184588 (version 69.37)

Entrez gene

5142

UniProt

Q07343

neXtProt

NX_Q07343

Antibodypedia

PDE4B antibodies
 

PROTEIN VIEW

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 « 
 
PDE4B-001
 
PDE4B-002
 
PDE4B-003
 
PDE4B-006
 
PDE4B-007
 
PDE4B-008
 
PDE4B-009
 
PDE4B-010
 
PDE4B-011
 
PDE4B-014
 
PDE4B-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PDE4B-001 ENSP00000332116
ENST00000329654
Q07343
Show all »
Show » Show » 736 83.3 No 0
PDE4B-002 ENSP00000342637
ENST00000341517
Q07343
Show all »
Show » Show » 736 83.3 No 0
PDE4B-003 ENSP00000392947
ENST00000423207
Q07343
Show all »
Show » Show » 721 82.1 No 0
PDE4B-006 ENSP00000432400
ENST00000491340
66 7.1 No 0
PDE4B-007 ENSP00000360084
ENST00000371045
Q5TEK5
Show all »
Show » Show » 564 64.4 No 0
PDE4B-008 ENSP00000432592
ENST00000480109
A5YW33
Show all »
Show » Show » 503 57.7 No 0
PDE4B-009 ENSP00000431909
ENST00000528771
E9PJ03
Show all »
Show » 137 15.9 No 0
PDE4B-010 ENSP00000437249
ENST00000531025
E9PNB0
Show all »
Show » 143 16.6 No 0
PDE4B-011 ENSP00000436104
ENST00000526197
E9PR34
Show all »
Show » 152 17.6 No 0
PDE4B-014 ENSP00000397548
ENST00000412480
E9PMG3
Show all »
147 16.3 No 0
PDE4B-201 ENSP00000360088
ENST00000371049
Q07343
Show all »
Show » Show » 736 83.3 No 0