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GENE INFORMATION
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The gene information section lists the gene name (HUGO Gene Nomenclature Committee ( HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version. The Entrez gene identifier for the gene is also given. If any of the protein products of the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the neXtProt databases for these proteins are displayed.
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Gene name |
PDE4B (HGNC Symbol) |
Synonyms |
DPDE4 |
Description |
phosphodiesterase 4B, cAMP-specific (HGNC Symbol) |
Entrez gene summary |
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
Chromosome |
1 (Chromosome progress)
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Cytoband |
p31.3 |
Chromosome location (bp) |
66258197 - 66840259 |
Ensembl |
ENSG00000184588 (version 69.37) |
Entrez gene |
5142 |
UniProt |
Q07343 |
neXtProt |
NX_Q07343 |
Antibodypedia |
PDE4B antibodies |
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PROTEIN VIEW
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The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green.
Common (purple) and unique (grey) regions between alternative processed transcripts from the same gene are also displayed ( read more), and at the bottom of the protein view is the protein scale.
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PROTEIN INFORMATION
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The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website for that protein, and the ENST identifier links to the Ensembl website for that transcript. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues) (according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius and predicted transmembrane region(s) (according to MDM) are also reported.
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Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length (aa) |
Molecular mass (kDa) |
Signal peptide (predicted) |
Transmembrane regions (predicted)
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| PDE4B-001 |
ENSP00000332116
ENST00000329654
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Q07343 Show all »
« Hide
Q07343 [Direct mapping]cAMP-specific 3',5'-cyclic phosphodiesterase 4B Q5TEK6 [Target identity:100%; Query identity:100%]Phosphodiesterase 4B, cAMP-specific (Phosphodiesterase E4 dunce homolog, Drosophila); cDNA FLJ75596, highly similar to Homo sapiens phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) (PDE4B), mRNA B1AN65 [Target identity:21%; Query identity:100%]Phosphodiesterase 4B, cAMP-specific (Phosphodiesterase E4 dunce homolog, Drosophila) E9PR34 [Target identity:20%; Query identity:100%]cAMP-specific 3',5'-cyclic phosphodiesterase 4B E9PNB0 [Target identity:19%; Query identity:100%]cAMP-specific 3',5'-cyclic phosphodiesterase 4B E9PJ03 [Target identity:18%; Query identity:100%]cAMP-specific 3',5'-cyclic phosphodiesterase 4B
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Enzymes Hydrolases Potential transmembrane proteins THUMBUP predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level
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Show »
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736 |
83.3 |
No |
0 |
| PDE4B-002 |
ENSP00000342637
ENST00000341517
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Q07343 Show all »
« Hide
Q07343 [Direct mapping]cAMP-specific 3',5'-cyclic phosphodiesterase 4B Q5TEK6 [Target identity:100%; Query identity:100%]Phosphodiesterase 4B, cAMP-specific (Phosphodiesterase E4 dunce homolog, Drosophila); cDNA FLJ75596, highly similar to Homo sapiens phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) (PDE4B), mRNA B1AN65 [Target identity:21%; Query identity:100%]Phosphodiesterase 4B, cAMP-specific (Phosphodiesterase E4 dunce homolog, Drosophila) E9PR34 [Target identity:20%; Query identity:100%]cAMP-specific 3',5'-cyclic phosphodiesterase 4B E9PNB0 [Target identity:19%; Query identity:100%]cAMP-specific 3',5'-cyclic phosphodiesterase 4B E9PJ03 [Target identity:18%; Query identity:100%]cAMP-specific 3',5'-cyclic phosphodiesterase 4B
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Show »
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Enzymes Hydrolases Potential transmembrane proteins THUMBUP predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level
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Show »
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736 |
83.3 |
No |
0 |
| PDE4B-003 |
ENSP00000392947
ENST00000423207
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Q07343 Show all »
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Q07343 [Direct mapping]cAMP-specific 3',5'-cyclic phosphodiesterase 4B Q5TEK4 [Target identity:100%; Query identity:100%]Phosphodiesterase 4B, cAMP-specific (Phosphodiesterase E4 dunce homolog, Drosophila); cDNA FLJ75521, highly similar to Homo sapiens cyclic AMP specific phosphodiesterase mRNA Q59GM8 [Target identity:100%; Query identity:99%]Phosphodiesterase 4B, cAMP-specific (Phosphodiesterase E4 dunce homolog, Drosophila) variant E9PR34 [Target identity:21%; Query identity:100%]cAMP-specific 3',5'-cyclic phosphodiesterase 4B E9PJ03 [Target identity:19%; Query identity:100%]cAMP-specific 3',5'-cyclic phosphodiesterase 4B E9PNB0 [Target identity:19%; Query identity:100%]cAMP-specific 3',5'-cyclic phosphodiesterase 4B
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Enzymes Hydrolases Potential transmembrane proteins THUMBUP predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level
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721 |
82.1 |
No |
0 |
| PDE4B-006 |
ENSP00000432400
ENST00000491340
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66 |
7.1 |
No |
0 |
| PDE4B-007 |
ENSP00000360084
ENST00000371045
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Q5TEK5 Show all »
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Q5TEK5 [Target identity:100%; Query identity:100%]Phosphodiesterase 4B, cAMP-specific (Phosphodiesterase E4 dunce homolog, Drosophila); Phosphodiesterase 4B, cAMP-specific (Phosphodiesterase E4 dunce homolog, Drosophila), isoform CRA_a; cAMP-specific 3',5'-cyclic phosphodiesterase 4B Q13945 [Target identity:100%; Query identity:93%]3',5'-cyclic AMP phosphodiesterase E9PR34 [Target identity:26%; Query identity:100%]cAMP-specific 3',5'-cyclic phosphodiesterase 4B E9PNB0 [Target identity:25%; Query identity:100%]cAMP-specific 3',5'-cyclic phosphodiesterase 4B E9PJ03 [Target identity:24%; Query identity:100%]cAMP-specific 3',5'-cyclic phosphodiesterase 4B
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Potential transmembrane proteins THUMBUP predicted membrane proteins
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Show »
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564 |
64.4 |
No |
0 |
| PDE4B-008 |
ENSP00000432592
ENST00000480109
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A5YW33 Show all »
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A5YW33 [Target identity:100%; Query identity:100%]cAMP-specific 3',5'-cyclic phosphodiesterase 4B; cAMP-specific phosphodiesterase-4 B isoform; cDNA FLJ75295
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Potential transmembrane proteins THUMBUP predicted membrane proteins
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503 |
57.7 |
No |
0 |
| PDE4B-009 |
ENSP00000431909
ENST00000528771
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E9PJ03 Show all »
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E9PJ03 [Target identity:100%; Query identity:100%]cAMP-specific 3',5'-cyclic phosphodiesterase 4B
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Show »
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137 |
15.9 |
No |
0 |
| PDE4B-010 |
ENSP00000437249
ENST00000531025
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E9PNB0 Show all »
« Hide
E9PNB0 [Target identity:100%; Query identity:100%]cAMP-specific 3',5'-cyclic phosphodiesterase 4B E9PJ03 [Target identity:95%; Query identity:100%]cAMP-specific 3',5'-cyclic phosphodiesterase 4B
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Show »
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143 |
16.6 |
No |
0 |
| PDE4B-011 |
ENSP00000436104
ENST00000526197
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E9PR34 Show all »
« Hide
E9PR34 [Target identity:100%; Query identity:100%]cAMP-specific 3',5'-cyclic phosphodiesterase 4B E9PNB0 [Target identity:94%; Query identity:100%]cAMP-specific 3',5'-cyclic phosphodiesterase 4B E9PJ03 [Target identity:90%; Query identity:100%]cAMP-specific 3',5'-cyclic phosphodiesterase 4B
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Show »
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152 |
17.6 |
No |
0 |
| PDE4B-014 |
ENSP00000397548
ENST00000412480
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E9PMG3 Show all »
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E9PMG3 [Target identity:100%; Query identity:100%]cAMP-specific 3',5'-cyclic phosphodiesterase 4B
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147 |
16.3 |
No |
0 |
| PDE4B-201 |
ENSP00000360088
ENST00000371049
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Q07343 Show all »
« Hide
Q07343 [Direct mapping]cAMP-specific 3',5'-cyclic phosphodiesterase 4B Q5TEK6 [Target identity:100%; Query identity:100%]Phosphodiesterase 4B, cAMP-specific (Phosphodiesterase E4 dunce homolog, Drosophila); cDNA FLJ75596, highly similar to Homo sapiens phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) (PDE4B), mRNA B1AN65 [Target identity:21%; Query identity:100%]Phosphodiesterase 4B, cAMP-specific (Phosphodiesterase E4 dunce homolog, Drosophila) E9PR34 [Target identity:20%; Query identity:100%]cAMP-specific 3',5'-cyclic phosphodiesterase 4B E9PNB0 [Target identity:19%; Query identity:100%]cAMP-specific 3',5'-cyclic phosphodiesterase 4B E9PJ03 [Target identity:18%; Query identity:100%]cAMP-specific 3',5'-cyclic phosphodiesterase 4B
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Show »
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Enzymes Hydrolases Potential transmembrane proteins THUMBUP predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level
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Show »
« Hide
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736 |
83.3 |
No |
0 |
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