USP18

GENERAL INFORMATION

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Gene name

USP18

Gene description

Ubiquitin specific peptidase 18

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Strong cytoplasmic and membranous positivity was observed in seminiferus ducts and superficial layers of squamous epithelia. Neuropil and Purkinje cells in the CNS were strongly stained. Smooth muscle displayed moderate cytoplasmic positivity. Remaining normal tissues were generally negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA044768
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Esophagus

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

USP18

Synonyms

Description

Ubiquitin specific peptidase 18 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011]

Chromosome

22

Cytoband

q11.21

Chromosome location (bp)

18149899 - 18177397

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000184979 (version 78.38)

Entrez gene

11274

UniProt

Q9UMW8 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UMW8

Antibodypedia

USP18 antibodies


PROTEIN BROWSER

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ENST00000215794
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

USP18-001 ENSP00000215794
ENST00000215794
Q9UMW8
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