USP18

GENE INFORMATION

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Gene name

USP18

Synonyms

Description

ubiquitin specific peptidase 18 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011]

Chromosome

22 (Chromosome progress)

Cytoband

q11.21

Chromosome location (bp)

18632666 - 18660164

Ensembl

ENSG00000184979 (version 73.37)

Entrez gene

11274

UniProt

Q9UMW8 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UMW8

Antibodypedia

USP18 antibodies
 

PROTEIN VIEW

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USP18-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

USP18-001 ENSP00000215794
ENST00000215794
Q9UMW8
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