CHRM5

GENERAL INFORMATION

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Gene name

CHRM5

Gene description

Cholinergic receptor, muscarinic 5

Protein class

FDA approved drug targets
G-protein coupled receptors
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (cerebral cortex, placenta, testis)
GTEx:Tissue enhanced (testis)

Protein evidence

Evidence at transcript level

Protein localization

RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining not consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.

Data reliability

Uncertain based on 1 antibody.
HPA013172
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (cerebral cortex, placenta, testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (testis)

Organ

Expression



GENE INFORMATION

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Gene name

CHRM5

Synonyms

Description

Cholinergic receptor, muscarinic 5 (HGNC Symbol)

Entrez gene summary

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels. [provided by RefSeq, Jul 2008]

Chromosome

15

Cytoband

q14

Chromosome location (bp)

33968720 - 34067457

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000184984 (version 78.38)

Entrez gene

1133

UniProt

P08912 (UniProt - Evidence at transcript level)

neXtProt

NX_P08912

Antibodypedia

CHRM5 antibodies


PROTEIN BROWSER

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ENST00000383263
 
ENST00000557872
 
ENST00000560035
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CHRM5-001 ENSP00000372750
ENST00000383263
P08912
Show all »
Show » Show » 532 60.1 No 7
CHRM5-002 ENSP00000453745
ENST00000557872
P08912
Show all »
Show » Show » 532 60.1 No 7
CHRM5-003 ENSP00000452742
ENST00000560035
H0YKC0
Show all »
Show » 22 2.4 No 0