SOCS1

GENE INFORMATION

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Gene name

SOCS1 (HGNC Symbol)

Synonyms

Cish1, JAB, SOCS-1, SSI-1, TIP3

Description

suppressor of cytokine signaling 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]

Chromosome

16 (Chromosome progress)

Cytoband

p13.13

Chromosome location (bp)

11348262 - 11350036

Ensembl

ENSG00000185338 (version 73.37)

Entrez gene

8651

UniProt

O15524 (UniProt - Evidence at protein level)

neXtProt

NX_O15524

Antibodypedia

SOCS1 antibodies
 

PROTEIN VIEW

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SOCS1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SOCS1-001 ENSP00000329418
ENST00000332029
O15524
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