PARK2

GENE INFORMATION

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Gene name

PARK2 (HGNC Symbol)

Synonyms

AR-JP, parkin, PDJ

Description

parkinson protein 2, E3 ubiquitin protein ligase (parkin) (HGNC Symbol)

Entrez gene summary

The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008]

Chromosome

6 (Chromosome progress)

Cytoband

q26

Chromosome location (bp)

161768452 - 163148803

Ensembl

ENSG00000185345 (version 73.37)

Entrez gene

5071

UniProt

O60260 (UniProt - Evidence at protein level)

neXtProt

NX_O60260

Antibodypedia

PARK2 antibodies
 

PROTEIN VIEW

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PARK2-001
 
PARK2-002
 
PARK2-003
 
PARK2-004
 
PARK2-005
 
PARK2-006
 
PARK2-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PARK2-001 ENSP00000355860
ENST00000366894
O60260
Show all »
Show » 274 30.6 No 0
PARK2-002 ENSP00000355858
ENST00000366892
B1AKC3
Show all »
Show » 368 40.5 No 0
PARK2-003 ENSP00000343589
ENST00000338468
O60260
Show all »
Show » 274 30.6 No 0
PARK2-004 ENSP00000355865
ENST00000366898
O60260
Show all »
Show » 465 51.6 No 0
PARK2-005 ENSP00000355863
ENST00000366897
O60260
Show all »
Show » 437 48.7 No 0
PARK2-006 ENSP00000355862
ENST00000366896
O60260
Show all »
Show » 316 35.6 No 0
PARK2-007 ENSP00000434414
ENST00000479615
O60260
Show all »
Show » 218 23.6 No 0