HGS

GENERAL INFORMATION

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Gene name

HGS

Gene description

Hepatocyte growth factor-regulated tyrosine kinase substrate

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in most tissues at variable levels. Highest expression in exocrine pancreatic cells.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA004872 , HPA007728
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

HGS (HGNC Symbol)

Synonyms

Hrs, Vps27, ZFYVE8

Description

Hepatocyte growth factor-regulated tyrosine kinase substrate (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010]

Chromosome

17

Cytoband

q25.3

Chromosome location (bp)

81683326 - 81703138

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000185359 (version 78.38)

Entrez gene

9146

UniProt

O14964 (UniProt - Evidence at protein level)

neXtProt

NX_O14964

Antibodypedia

HGS antibodies


PROTEIN BROWSER

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ENST00000329138
 
ENST00000571237
 
ENST00000571518
 
ENST00000572392
 
ENST00000573320
 
ENST00000575078
 
ENST00000577012
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HGS-001 ENSP00000331201
ENST00000329138
O14964
Show all »
Show » Show » 777 86.2 No 0
HGS-003 ENSP00000459685
ENST00000571518
I3L2H4
Show all »
Show » Show » 59 7 No 0
HGS-008 ENSP00000458987
ENST00000572392
I3L1P5
Show all »
Show » Show » 263 30 No 0
HGS-011 ENSP00000458603
ENST00000577012
I3L165
Show all »
Show » Show » 71 8.4 No 0
HGS-013 ENSP00000458775
ENST00000571237
I3L1E3
Show all »
Show » 292 32.4 No 0
HGS-017 ENSP00000460130
ENST00000575078
I3L326
Show all »
Show » 110 12 No 0
HGS-018 ENSP00000458789
ENST00000573320
Show » 63 6.8 No 0