BRCC3

GENE INFORMATION

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Gene name

BRCC3 (HGNC Symbol)

Synonyms

BRCC36, C6.1A, CXorf53

Description

BRCA1/BRCA2-containing complex, subunit 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011]

Chromosome

X (Chromosome progress)

Cytoband

q28

Chromosome location (bp)

154299695 - 154351349

Ensembl

ENSG00000185515 (version 73.37)

Entrez gene

79184

UniProt

P46736 (UniProt - Evidence at protein level)

neXtProt

NX_P46736

Antibodypedia

BRCC3 antibodies
 

PROTEIN VIEW

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BRCC3-001
 
BRCC3-002
 
BRCC3-003
 
BRCC3-004
 
BRCC3-005
 
BRCC3-006
 
BRCC3-007
 
BRCC3-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BRCC3-001 ENSP00000358474
ENST00000369462
P46736
Show all »
Show » Show » 316 36.1 No 0
BRCC3-002 ENSP00000328641
ENST00000330045
P46736
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Show » Show » 291 33.1 No 0
BRCC3-003 ENSP00000381988
ENST00000399026
P46736
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Show » Show » 90 10.4 No 0
BRCC3-004 ENSP00000358471
ENST00000369459
P46736
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Show » Show » 247 28 No 0
BRCC3-005 ENSP00000415152
ENST00000453705
Show » 85 9.3 No 0
BRCC3-006 ENSP00000344103
ENST00000340647
P46736
Show all »
Show » Show » 292 33.2 No 0
BRCC3-007 ENSP00000413170
ENST00000411985
P46736
Show all »
Show » Show » 226 25.8 No 0
BRCC3-201 ENSP00000381998
ENST00000399042
H9KVA9
Show all »
Show » 317 36.1 No 0