PRKG1

GENE INFORMATION

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Gene name

PRKG1 (HGNC Symbol)

Synonyms

PGK, PKG, PRKG1B, PRKGR1B

Description

protein kinase, cGMP-dependent, type I (HGNC Symbol)

Entrez gene summary

Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011]

Chromosome

10 (Chromosome progress)

Cytoband

q11.23

Chromosome location (bp)

52750945 - 54058110

Ensembl

ENSG00000185532 (version 73.37)

Entrez gene

5592

UniProt

Q13976 (UniProt - Evidence at protein level)

neXtProt

NX_Q13976

Antibodypedia

PRKG1 antibodies
 

PROTEIN VIEW

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PRKG1-001
 
PRKG1-002
 
PRKG1-004
 
PRKG1-005
 
PRKG1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRKG1-001 ENSP00000363097
ENST00000373985
Q5SQU3
Show all »
Show » Show » 659 75 No 0
PRKG1-002 ENSP00000363092
ENST00000373980
Q13976
Show all »
Show » Show » 686 77.8 No 0
PRKG1-004 ENSP00000363087
ENST00000373976
B1ALS0
Show all »
Show » 181 20.5 No 0
PRKG1-005 ENSP00000363086
ENST00000373975
Q5JP05
Show all »
Show » Show » 389 44.2 No 0
PRKG1-201 ENSP00000384200
ENST00000401604
Q13976
Show all »
Show » Show » 671 76.4 No 0