SP1

GENERAL INFORMATION

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Gene name

SP1

Gene description

Sp1 transcription factor

Protein class

Cancer-related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous nuclear expression with variable intensities.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA001853 , HPA012292 , CAB000330
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

SP1

Synonyms

Description

Sp1 transcription factor (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

Chromosome

12

Cytoband

q13.13

Chromosome location (bp)

53380176 - 53416446

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000185591 (version 78.38)

Entrez gene

6667

UniProt

P08047 (UniProt - Evidence at protein level)

neXtProt

NX_P08047

Antibodypedia

SP1 antibodies


PROTEIN BROWSER

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ENST00000327443
 
ENST00000426431
 
ENST00000548560
 
ENST00000551969
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SP1-001 ENSP00000329357
ENST00000327443
P08047
Show all »
Show » Show » 785 80.7 No 0
SP1-002 ENSP00000404263
ENST00000426431
P08047
Show all »
Show » Show » 778 79.9 No 0
SP1-003 ENSP00000457804
ENST00000551969
H3BUU5
Show all »
Show » 162 16.1 No 0
SP1-004 ENSP00000458133
ENST00000548560
H3BVI2
Show all »
Show » Show » 230 23 No 0