SP1

GENE INFORMATION

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Gene name

SP1

Synonyms

Description

Sp1 transcription factor (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Chromosome

12 (Chromosome progress)

Cytoband

q13.13

Chromosome location (bp)

53773960 - 53810230

Ensembl

ENSG00000185591 (version 73.37)

Entrez gene

6667

UniProt

P08047 (UniProt - Evidence at protein level)

neXtProt

NX_P08047

Antibodypedia

SP1 antibodies
 

PROTEIN VIEW

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SP1-001
 
SP1-002
 
SP1-003
 
SP1-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SP1-001 ENSP00000329357
ENST00000327443
P08047
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Show » Show » 785 80.7 No 0
SP1-002 ENSP00000404263
ENST00000426431
G5E9M8
Show all »
Show » Show » 778 79.9 No 0
SP1-003 ENSP00000457804
ENST00000551969
H3BUU5
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162 16.1 No 0
SP1-004 ENSP00000458133
ENST00000548560
H3BVI2
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Show » Show » 230 23 No 0