MRPL40

GENE INFORMATION

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Gene name

MRPL40 (HGNC Symbol)

Synonyms

MRP-L22, NLVCF

Description

mitochondrial ribosomal protein L40 (HGNC Symbol)

Entrez gene summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Deletions in this gene may contribute to the etiology of velo-cardio-facial syndrome and DiGeorge syndrome. [provided by RefSeq, Jul 2008]

Chromosome

22 (Chromosome progress)

Cytoband

q11.21

Chromosome location (bp)

19419425 - 19423598

Ensembl

ENSG00000185608 (version 73.37)

Entrez gene

64976

UniProt

Q9NQ50 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NQ50

Antibodypedia

MRPL40 antibodies
 

PROTEIN VIEW

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MRPL40-001
 
MRPL40-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MRPL40-001 ENSP00000333401
ENST00000333130
Q9NQ50
Show all »
Show » 206 24.5 No 0
MRPL40-002 ENSP00000411864
ENST00000443660
F8WBK5
Show all »
Show » 162 19.5 No 0