P4HB

GENE INFORMATION

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Gene name

P4HB (HGNC Symbol)

Synonyms

DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PO4DB, PO4HB, PROHB

Description

prolyl 4-hydroxylase, beta polypeptide (HGNC Symbol)

Entrez gene summary

This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]

Chromosome

17 (Chromosome progress)

Cytoband

q25.3

Chromosome location (bp)

79801035 - 79818570

Ensembl

ENSG00000185624 (version 73.37)

Entrez gene

5034

UniProt

P07237 (UniProt - Evidence at protein level)

neXtProt

NX_P07237

Antibodypedia

P4HB antibodies
 

PROTEIN VIEW

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 « 
 
P4HB-001
 
P4HB-002
 
P4HB-014
 
P4HB-019
 
P4HB-021
 
P4HB-022
 
P4HB-023
 
P4HB-024
 
P4HB-025
 
P4HB-026
 
P4HB-027
 
P4HB-029
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

P4HB-001 ENSP00000327801
ENST00000331483
P07237
Show all »
Show » Show » 508 57.1 Yes 0
P4HB-002 ENSP00000388117
ENST00000415593
B3KTQ9
Show all »
Show » 274 31.4 No 0
P4HB-014 ENSP00000459211
ENST00000575069
I3L1Y5
Show all »
54 5.8 Yes 0
P4HB-019 ENSP00000460612
ENST00000574914
I3L3P5
Show all »
Show » 156 16.9 Yes 0
P4HB-021 ENSP00000388374
ENST00000439918
H7BZ94
Show all »
Show » 464 52.5 Yes 0
P4HB-022 ENSP00000460088
ENST00000573778
I3L312
Show all »
Show » 208 23 Yes 0
P4HB-023 ENSP00000461718
ENST00000576390
I3L514
Show all »
Show » Show » 106 11.6 Yes 0
P4HB-024 ENSP00000461791
ENST00000576052
I3NI03
Show all »
Show » 166 18.5 Yes 0
P4HB-025 ENSP00000458300
ENST00000571617
I3L0S0
Show all »
Show » 148 16.2 Yes 0
P4HB-026 ENSP00000460285
ENST00000576380
I3L398
Show all »
200 23 No 0
P4HB-027 ENSP00000460741
ENST00000576541
I3L3U6
Show all »
Show » 188 20.7 Yes 0
P4HB-029 ENSP00000461362
ENST00000570907
I3L4M2
Show all »
117 13.5 No 0