PBX1

GENE INFORMATION

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Gene name

PBX1

Synonyms

Description

Pre-B-cell leukemia homeobox 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Chromosome

1

Cytoband

q23.3

Chromosome location (bp)

164524821 - 164868533

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000185630 (version 75.37)

Entrez gene

5087

UniProt

P40424 (UniProt - Evidence at protein level)

neXtProt

NX_P40424

Antibodypedia

PBX1 antibodies
 

PROTEIN VIEW

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 « 
 
PBX1-001
 
PBX1-002
 
PBX1-006
 
PBX1-007
 
PBX1-009
 
PBX1-012
 
PBX1-013
 
PBX1-017
 
PBX1-018
 
PBX1-019
 
PBX1-201
 
PBX1-202
 
PBX1-203
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PBX1-001 ENSP00000405890
ENST00000420696
P40424
Show all »
Show » Show » 430 46.6 No 0
PBX1-002 ENSP00000356872
ENST00000367897
P40424
Show all »
Show » Show » 347 38.4 No 0
PBX1-006 ENSP00000473998
ENST00000485769
S4R377
Show all »
Show » Show » 70 7.4 No 0
PBX1-007 ENSP00000341455
ENST00000340699
F8WA05
Show all »
Show » Show » 170 18.2 No 0
PBX1-009 ENSP00000453163
ENST00000482110
H0YLD4
Show all »
Show » Show » 129 14.3 No 0
PBX1-012 ENSP00000453188
ENST00000559240
H0YLF5
Show all »
Show » Show » 339 37 No 0
PBX1-013 ENSP00000452804
ENST00000559578
H0YKH1
Show all »
Show » Show » 159 17.6 No 0
PBX1-017 ENSP00000452727
ENST00000560641
H0YLB0
Show all »
Show » Show » 325 35.2 No 0
PBX1-018 ENSP00000453262
ENST00000559560
H0YLM3
Show all »
Show » Show » 97 10.5 No 0
PBX1-019 ENSP00000453331
ENST00000558837
H0YLT4
Show all »
Show » Show » 139 15.6 No 0
PBX1-201 ENSP00000384856
ENST00000401534
P40424
Show all »
Show » Show » 347 38.4 No 0
PBX1-202 ENSP00000439943
ENST00000540236
P40424
Show all »
Show » Show » 420 46.3 No 0
PBX1-203 ENSP00000440869
ENST00000540246
B7Z774
Show all »
Show » Show » 301 33 No 0