PRAME

GENERAL INFORMATION

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Gene name

PRAME

Gene description

Preferentially expressed antigen in melanoma

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

10
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein localization

A majority of normal tissues showed moderate to strong cytoplasmic staining which often showed a granular pattern. Pneumocytes, hepatocytes, cells in the CNS and lymphoid non-germinal center cells were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA045153
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (testis)

Organ

Expression



GENE INFORMATION

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Gene name

PRAME (HGNC Symbol)

Synonyms

CT130, MAPE

Description

Preferentially expressed antigen in melanoma (HGNC Symbol)

Entrez gene summary

This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Chromosome

22

Cytoband

q11.22

Chromosome location (bp)

22547701 - 22559361

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000185686 (version 78.38)

Entrez gene

23532

UniProt

P78395 (UniProt - Evidence at protein level)

neXtProt

NX_P78395

Antibodypedia

PRAME antibodies


PROTEIN BROWSER

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ENST00000398741
 
ENST00000398743
 
ENST00000402697
 
ENST00000403441
 
ENST00000405655
 
ENST00000406503
 
ENST00000420709
 
ENST00000438888
 
ENST00000439106
 
ENST00000543184
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRAME-001 ENSP00000381728
ENST00000398743
P78395
Show all »
Show » Show » 509 57.9 No 0
PRAME-003 ENSP00000385198
ENST00000402697
P78395
Show all »
Show » Show » 509 57.9 No 0
PRAME-004 ENSP00000384343
ENST00000405655
P78395
Show all »
Show » Show » 509 57.9 No 0
PRAME-005 ENSP00000407320
ENST00000439106
E7EW99
Show all »
Show » 201 23.1 No 0
PRAME-006 ENSP00000384058
ENST00000406503
B5MCY4
Show all »
Show » 115 13.1 No 0
PRAME-008 ENSP00000412318
ENST00000420709
E7EMH2
Show all »
Show » 152 17.5 No 0
PRAME-009 ENSP00000385091
ENST00000403441
B5MD04
Show all »
Show » 86 9.8 No 0
PRAME-012 ENSP00000407121
ENST00000438888
Show » 189 21.1 No 0
PRAME-201 ENSP00000381726
ENST00000398741
P78395
Show all »
Show » Show » 509 57.9 No 0
PRAME-202 ENSP00000445675
ENST00000543184
P78395
Show all »
Show » Show » 509 57.9 No 0