PRAME

GENE INFORMATION

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Gene name

PRAME (HGNC Symbol)

Synonyms

CT130, MAPE

Description

preferentially expressed antigen in melanoma (HGNC Symbol)

Entrez gene summary

This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]

Chromosome

22 (Chromosome progress)

Cytoband

q11.22

Chromosome location (bp)

22890123 - 22901768

Ensembl

ENSG00000185686 (version 73.37)

Entrez gene

23532

UniProt

P78395 (UniProt - Evidence at protein level)

neXtProt

NX_P78395

Antibodypedia

PRAME antibodies
 

PROTEIN VIEW

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 « 
 
PRAME-001
 
PRAME-003
 
PRAME-004
 
PRAME-005
 
PRAME-006
 
PRAME-008
 
PRAME-009
 
PRAME-011
 
PRAME-012
 
PRAME-201
 
PRAME-202
 
PRAME-203
 
PRAME-204
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRAME-001 ENSP00000381728
ENST00000398743
P78395
Show all »
Show » Show » 509 57.9 No 0
PRAME-003 ENSP00000385198
ENST00000402697
P78395
Show all »
Show » Show » 509 57.9 No 0
PRAME-004 ENSP00000384343
ENST00000405655
P78395
Show all »
Show » Show » 509 57.9 No 0
PRAME-005 ENSP00000407320
ENST00000439106
E7EW99
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201 23.1 No 0
PRAME-006 ENSP00000384058
ENST00000406503
B5MCY4
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115 13.1 No 0
PRAME-008 ENSP00000412318
ENST00000420709
E7EMH2
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152 17.5 No 0
PRAME-009 ENSP00000385091
ENST00000403441
B5MD04
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86 9.8 No 0
PRAME-011 ENSP00000399816
ENST00000442481
F8WF80
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64 7.4 No 0
PRAME-012 ENSP00000407121
ENST00000438888
189 21.1 No 0
PRAME-201 ENSP00000381726
ENST00000398741
P78395
Show all »
Show » Show » 509 57.9 No 0
PRAME-202 ENSP00000407342
ENST00000424204
F5H4B1
Show all »
Show » 493 55.9 No 0
PRAME-203 ENSP00000445097
ENST00000539862
F5H4B1
Show all »
Show » 493 55.9 No 0
PRAME-204 ENSP00000445675
ENST00000543184
P78395
Show all »
Show » Show » 509 57.9 No 0