PIGP

GENE INFORMATION

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Gene name

PIGP (HGNC Symbol)

Synonyms

DCRC, DSCR5, DSRC

Description

phosphatidylinositol glycan anchor biosynthesis, class P (HGNC Symbol)

Entrez gene summary

This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

21 (Chromosome progress)

Cytoband

q22.13

Chromosome location (bp)

38435146 - 38445470

Ensembl

ENSG00000185808 (version 73.37)

Entrez gene

51227

UniProt

P57054 (UniProt - Evidence at protein level)

neXtProt

NX_P57054

Antibodypedia

PIGP antibodies
 

PROTEIN VIEW

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PIGP-001
 
PIGP-002
 
PIGP-003
 
PIGP-004
 
PIGP-005
 
PIGP-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PIGP-001 ENSP00000353719
ENST00000360525
P57054
Show all »
Show » Show » 134 15.4 No 2
PIGP-002 ENSP00000382053
ENST00000399102
P57054
Show all »
Show » Show » 134 15.4 No 2
PIGP-003 ENSP00000382049
ENST00000399098
P57054
Show all »
Show » Show » 108 12.5 No 1
PIGP-004 ENSP00000420037
ENST00000464265
P57054
Show all »
Show » Show » 158 18.1 Yes 2
PIGP-005 ENSP00000382054
ENST00000399103
P57054
Show all »
Show » Show » 134 15.4 No 2
PIGP-007 ENSP00000388372
ENST00000430792
C9JKT1
Show all »
25 3 No 0