ATP6V0C

GENERAL INFORMATION

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Gene name

ATP6V0C

Gene description

ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c

Protein class

Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Not detected

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY

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Data reliability

Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A


PROTEIN EXPRESSION OVERVIEW

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Pending normal tissue annotation.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Not detected

Organ

Expression



GENE INFORMATION

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Gene name

ATP6V0C (HGNC Symbol)

Synonyms

ATP6C, ATP6L, ATPL, VATL, Vma3

Description

ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c (HGNC Symbol)

Entrez gene summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c"", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010]

Chromosome

16

Cytoband

p13.3

Chromosome location (bp)

2513726 - 2520223

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000185883 (version 78.38)

Entrez gene

527

UniProt

P27449 (UniProt - Evidence at protein level)

neXtProt

NX_P27449

Antibodypedia

ATP6V0C antibodies


PROTEIN BROWSER

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ENST00000330398
 
ENST00000564973
 
ENST00000565223
 
ENST00000568562
 
ENST00000618152
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP6V0C-001 ENSP00000329757
ENST00000330398
P27449
Show all »
Show » Show » 155 15.7 No 3
ATP6V0C-003 ENSP00000454597
ENST00000568562
H3BMY0
Show all »
Show » 63 7.1 No 0
ATP6V0C-004 ENSP00000457782
ENST00000565223
H3BNI4
Show all »
Show » Show » 112 11.6 No 3
ATP6V0C-005 ENSP00000454868
ENST00000564973
H3BNI4
Show all »
Show » Show » 112 11.6 No 3
ATP6V0C-201 ENSP00000481778
ENST00000618152
P27449
Show all »
Show » Show » 155 15.7 No 3