ATP6V0C

GENE INFORMATION

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Gene name

ATP6V0C (HGNC Symbol)

Synonyms

ATP6C, ATP6L, ATPL, VATL, Vma3

Description

ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c (HGNC Symbol)

Entrez gene summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c"", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010]

Chromosome

16 (Chromosome progress)

Cytoband

p13.3

Chromosome location (bp)

2563871 - 2570219

Ensembl

ENSG00000185883 (version 73.37)

Entrez gene

527

UniProt

P27449 (UniProt - Evidence at protein level)

neXtProt

NX_P27449

Antibodypedia

ATP6V0C antibodies
 

PROTEIN VIEW

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ATP6V0C-001
 
ATP6V0C-003
 
ATP6V0C-004
 
ATP6V0C-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP6V0C-001 ENSP00000329757
ENST00000330398
P27449
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Show » Show » 155 15.7 No 3
ATP6V0C-003 ENSP00000454597
ENST00000568562
H3BMY0
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63 7.1 No 0
ATP6V0C-004 ENSP00000457782
ENST00000565223
H3BNI4
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Show » Show » 112 11.6 No 3
ATP6V0C-005 ENSP00000454868
ENST00000564973
H3BNI4
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Show » Show » 112 11.6 No 3