BTLA

GENERAL INFORMATION

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Gene name

BTLA

Gene description

B and T lymphocyte associated

Protein class

CD markers
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (appendix, lymph node, spleen, tonsil)
GTEx:Group enriched (small intestine, spleen)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression of lymphoid cells.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 2 antibodies.
HPA047211 , HPA062029
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (appendix, lymph node, spleen, tonsil)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (small intestine, spleen)

Organ

Expression



GENE INFORMATION

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Gene name

BTLA (HGNC Symbol)

Synonyms

BTLA1, CD272

Description

B and T lymphocyte associated (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis. [provided by RefSeq, Aug 2011]

Chromosome

3

Cytoband

q13.2

Chromosome location (bp)

112463968 - 112499561

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000186265 (version 78.38)

Entrez gene

151888

UniProt

Q7Z6A9 (UniProt - Evidence at protein level)

neXtProt

NX_Q7Z6A9

Antibodypedia

BTLA antibodies


PROTEIN BROWSER

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ENST00000334529
 
ENST00000383680
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BTLA-001 ENSP00000333919
ENST00000334529
Q7Z6A9
Show all »
Show » Show » 289 32.8 No 1
BTLA-002 ENSP00000373178
ENST00000383680
Q7Z6A9
Show all »
Show » Show » 241 27.3 No 0