GABRA5

GENERAL INFORMATION

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Gene name

GABRA5

Gene description

Gamma-aminobutyric acid (GABA) A receptor, alpha 5

Protein class

FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Intracellular,Membrane,Secreted

Number of transcripts

9
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (cerebral cortex, hippocampus)

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY

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Data reliability

Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A


PROTEIN EXPRESSION OVERVIEW

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Pending normal tissue annotation.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (cerebral cortex)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (cerebral cortex, hippocampus)

Organ

Expression



GENE INFORMATION

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Gene name

GABRA5

Synonyms

Description

Gamma-aminobutyric acid (GABA) A receptor, alpha 5 (HGNC Symbol)

Entrez gene summary

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. [provided by RefSeq, Jul 2008]

Chromosome

15

Cytoband

q12

Chromosome location (bp)

26866363 - 26949207

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000186297 (version 78.38)

Entrez gene

2558

UniProt

P31644 (UniProt - Evidence at protein level)

neXtProt

NX_P31644

Antibodypedia

GABRA5 antibodies


PROTEIN BROWSER

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ENST00000335625
 
ENST00000355395
 
ENST00000400081
 
ENST00000554038
 
ENST00000554083
 
ENST00000554596
 
ENST00000554599
 
ENST00000555060
 
ENST00000555182
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GABRA5-001 ENSP00000335592
ENST00000335625
P31644
Show all »
Show » Show » 462 52.1 Yes 4
GABRA5-002 ENSP00000347557
ENST00000355395
P31644
Show all »
Show » Show » 462 52.1 Yes 4
GABRA5-004 ENSP00000451527
ENST00000554038
G3V408
Show all »
Show » Show » 86 9.7 Yes 0
GABRA5-005 ENSP00000450806
ENST00000554596
G3V2Q9
Show all »
Show » Show » 149 17.2 Yes 0
GABRA5-007 ENSP00000450932
ENST00000555060
Show » 16 1.8 No 0
GABRA5-008 ENSP00000450717
ENST00000554599
G3V2K2
Show all »
Show » Show » 166 19.2 Yes 0
GABRA5-009 ENSP00000450529
ENST00000554083
G3V296
Show all »
Show » Show » 86 10.1 No 0
GABRA5-010 ENSP00000450653
ENST00000555182
G3V2G8
Show all »
Show » Show » 166 19.1 No 0
GABRA5-201 ENSP00000382953
ENST00000400081
P31644
Show all »
Show » Show » 462 52.1 Yes 4