BACE1

GENE INFORMATION

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Gene name

BACE1 (HGNC Symbol)

Synonyms

BACE

Description

beta-site APP-cleaving enzyme 1 (HGNC Symbol)

Entrez gene summary

Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

Chromosome

11 (Chromosome progress)

Cytoband

q23.3

Chromosome location (bp)

117156402 - 117186975

Ensembl

ENSG00000186318 (version 73.37)

Entrez gene

23621

UniProt

P56817 (UniProt - Evidence at protein level)

neXtProt

NX_P56817

Antibodypedia

BACE1 antibodies
 

PROTEIN VIEW

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BACE1-001
 
BACE1-002
 
BACE1-003
 
BACE1-004
 
BACE1-006
 
BACE1-007
 
BACE1-008
 
BACE1-009
 
BACE1-013
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BACE1-001 ENSP00000318585
ENST00000313005
P56817
Show all »
Show » Show » 501 55.7 Yes 1
BACE1-002 ENSP00000402228
ENST00000428381
P56817
Show all »
Show » Show » 432 48.2 Yes 1
BACE1-003 ENSP00000424536
ENST00000513780
P56817
Show all »
Show » Show » 476 52.9 Yes 1
BACE1-004 ENSP00000403685
ENST00000445823
P56817
Show all »
Show » Show » 457 51 Yes 1
BACE1-006 ENSP00000475405
ENST00000392937
Show » Show » 401 45 No 1
BACE1-007 ENSP00000422461
ENST00000510630
P56817
Show all »
Show » Show » 376 42.1 No 1
BACE1-008 ENSP00000434486
ENST00000504995
Show » 40 4.8 No 0
BACE1-009 ENSP00000475171
ENST00000510915
Show » 51 6.2 No 0
BACE1-013 ENSP00000431848
ENST00000528053
E9PJG7
Show all »
Show » Show » 467 52 Yes 1