INSIG1

GENE INFORMATION

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Gene name

INSIG1 (HGNC Symbol)

Synonyms

CL-6, MGC1405

Description

insulin induced gene 1 (HGNC Symbol)

Entrez gene summary

Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jun 2009]

Chromosome

7 (Chromosome progress)

Cytoband

q36.2

Chromosome location (bp)

155089486 - 155101945

Ensembl

ENSG00000186480 (version 73.37)

Entrez gene

3638

UniProt

O15503 (UniProt - Evidence at protein level)

neXtProt

NX_O15503

Antibodypedia

INSIG1 antibodies
 

PROTEIN VIEW

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INSIG1-001
 
INSIG1-002
 
INSIG1-003
 
INSIG1-005
 
INSIG1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

INSIG1-001 ENSP00000344741
ENST00000340368
O15503
Show all »
Show » Show » 277 30 No 6
INSIG1-002 ENSP00000414691
ENST00000425172
C9JSG8
Show all »
Show » Show » 123 13.2 No 1
INSIG1-003 ENSP00000344035
ENST00000342407
O15503
Show all »
Show » Show » 164 17.5 No 1
INSIG1-005 ENSP00000420198
ENST00000476756
Show » 239 26.7 Yes 4
INSIG1-201 ENSP00000340010
ENST00000344756
F5H6P3
Show all »
Show » 178 20.4 No 3