BCR

GENE INFORMATION

? »

Gene name

BCR (HGNC Symbol)

Synonyms

ALL, BCR1, CML, D22S11, D22S662, PHL

Description

breakpoint cluster region (HGNC Symbol)

Entrez gene summary

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

22 (Chromosome progress)

Cytoband

q11.23

Chromosome location (bp)

23521891 - 23660224

Ensembl

ENSG00000186716 (version 73.37)

Entrez gene

613

UniProt

P11274 (UniProt - Evidence at protein level)

neXtProt

NX_P11274

Antibodypedia

BCR antibodies
 

PROTEIN VIEW

? »
 
 
 
BCR-001
 
BCR-002
 
BCR-006
 
BCR-201
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BCR-001 ENSP00000303507
ENST00000305877
P11274
Show all »
Show » Show » 1271 142.8 No 0
BCR-002 ENSP00000352535
ENST00000359540
P11274
Show all »
Show » Show » 1227 137.7 No 0
BCR-006 ENSP00000396531
ENST00000427791
H0Y554
Show all »
Show » Show » 257 29.6 No 0
BCR-201 ENSP00000381524
ENST00000398512
A9UF05
Show all »
Show » Show » 467 51.4 No 0