CXCR3

GENE INFORMATION

? »

Gene name

CXCR3 (HGNC Symbol)

Synonyms

CD183, CKR-L2, CMKAR3, GPR9, IP10-R, MigR

Description

chemokine (C-X-C motif) receptor 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]

Chromosome

X (Chromosome progress)

Cytoband

q13.1

Chromosome location (bp)

70835766 - 70838367

Ensembl

ENSG00000186810 (version 73.37)

Entrez gene

2833

UniProt

P49682 (UniProt - Evidence at protein level)

neXtProt

NX_P49682

Antibodypedia

CXCR3 antibodies
 

PROTEIN VIEW

? »
 
 
 
CXCR3-001
 
CXCR3-002
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CXCR3-001 ENSP00000362795
ENST00000373691
P49682
Show all »
Show » Show » 415 45.5 No 7
CXCR3-002 ENSP00000362797
ENST00000373693
P49682
Show all »
Show » Show » 368 40.7 No 7