RHD

GENE INFORMATION

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Gene name

RHD (HGNC Symbol)

Synonyms

CD240D, DIIIc, RH, Rh30a, Rh4, RhII, RhPI

Description

Rh blood group, D antigen (HGNC Symbol)

Entrez gene summary

The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene, which encodes the RhD protein, and a second gene that encodes both the RhC and RhE antigens on a single polypeptide. The two genes, and a third unrelated gene, are found in a cluster on chromosome 1. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

p36.11

Chromosome location (bp)

25598884 - 25656936

Ensembl

ENSG00000187010 (version 73.37)

Entrez gene

6007

UniProt

Q02161 (UniProt - Evidence at protein level)

neXtProt

NX_Q02161

Antibodypedia

RHD antibodies
 

PROTEIN VIEW

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RHD-001
 
RHD-004
 
RHD-005
 
RHD-006
 
RHD-007
 
RHD-008
 
RHD-009
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RHD-001 ENSP00000331871
ENST00000328664
Q02161
Show all »
Show » Show » 417 45.2 No >9
RHD-004 ENSP00000413849
ENST00000454452
Q02161
Show all »
Show » Show » 321 34.8 No 9
RHD-005 ENSP00000396420
ENST00000417538
Q5XLT2
Show all »
Show » Show » 378 41.7 No 9
RHD-006 ENSP00000350150
ENST00000357542
Q5XLT1
Show all »
Show » Show » 396 43.3 No >9
RHD-007 ENSP00000456966
ENST00000568195
H3BT10
Show all »
Show » Show » 463 50.2 No >9
RHD-008 ENSP00000339577
ENST00000342055
Q5XLS9
Show all »
Show » Show » 493 53.6 No >9
RHD-009 ENSP00000399640
ENST00000423810
E7EVW1
Show all »
Show » Show » 431 46.3 No >9