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GENE INFORMATION
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The gene information section lists the gene name (HUGO Gene Nomenclature Committee ( HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version. The Entrez gene identifier for the gene is also given. If any of the protein products of the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the neXtProt databases for these proteins are displayed.
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Gene name |
RHD (HGNC Symbol) |
Synonyms |
CD240D, DIIIc, RH, Rh30a, Rh4, RhII, RhPI |
Description |
Rh blood group, D antigen (HGNC Symbol) |
Entrez gene summary |
The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene, which encodes the RhD protein, and a second gene that encodes both the RhC and RhE antigens on a single polypeptide. The two genes, and a third unrelated gene, are found in a cluster on chromosome 1. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
Chromosome |
1 (Chromosome progress)
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Cytoband |
p36.11 |
Chromosome location (bp) |
25598884 - 25656936 |
Ensembl |
ENSG00000187010 (version 69.37) |
Entrez gene |
6007 |
UniProt |
Q02161 |
neXtProt |
NX_Q02161 |
Antibodypedia |
RHD antibodies |
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PROTEIN VIEW
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The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green.
Common (purple) and unique (grey) regions between alternative processed transcripts from the same gene are also displayed ( read more), and at the bottom of the protein view is the protein scale.
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PROTEIN INFORMATION
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The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website for that protein, and the ENST identifier links to the Ensembl website for that transcript. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues) (according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius and predicted transmembrane region(s) (according to MDM) are also reported.
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Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length (aa) |
Molecular mass (kDa) |
Signal peptide (predicted) |
Transmembrane regions (predicted)
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| RHD-001 |
ENSP00000331871
ENST00000328664
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Q02161 Show all »
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Q02161 [Direct mapping]Blood group Rh(D) polypeptide F5GXS3 [Target identity:100%; Query identity:85%]Blood group Rh(D) polypeptide I2HA01 [Target identity:82%; Query identity:100%]Rhesus blood group D antigen B4F4S0 [Target identity:76%; Query identity:100%]Rhesus blood group, D antigen E7BAS5 [Target identity:73%; Query identity:100%]Rhesus blood group, D antigen B4F4S7 [Target identity:64%; Query identity:100%]Rhesus blood group, D antigen I2HA00 [Target identity:61%; Query identity:100%]Rhesus blood group D antigen B2ZGQ0 [Target identity:30%; Query identity:100%]Truncated Rhesus blood group D antigen Q9UDZ3 [Target identity:29%; Query identity:100%]RHD protein D8MJ84 [Target identity:14%; Query identity:100%]Rh blood group D antigen P78522 [Target identity:14%; Query identity:100%]Rh blood group C antigen; Rh blood group D antigen; Rh blood group, CcEe antigens; Rh blood group, D antigen Q49IM6 [Target identity:13%; Query identity:100%]Rh blood group, D antigen; Rhesus blood group D antigen Q6A1H1 [Target identity:12%; Query identity:100%]Rhesus blood group D antigen A0PFK1 [Target identity:11%; Query identity:100%]Rhesus blood group C antigen A9P3T3 [Target identity:11%; Query identity:100%]Rh blood group RHD; RhD antigen; Rhesus blood group D antigen D2CRH1 [Target identity:11%; Query identity:100%]Rhesus blood group D antigen I0CKG6 [Target identity:11%; Query identity:100%]Rh blood group D antigen Q9UEC7 [Target identity:11%; Query identity:100%]RhC protein; RhD; Rhesus blood group D antigen A7Y8S3 [Target identity:10%; Query identity:100%]Rhesus blood group D antigen Q5NDM5 [Target identity:10%; Query identity:100%]Rhesus blood group C antigen D8MJ86 [Target identity:8%; Query identity:100%]Truncated Rh blood group D antigen G0TQY3 [Target identity:8%; Query identity:100%]Rhesus blood group D antigen Q8NFY2 [Target identity:5%; Query identity:100%]Rh blood group, D antigen; Rhesus blood group D antigen
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CD markers Blood group antigen proteins Transporters Transporter channels and pores Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins >9TM proteins predicted by MDM Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level
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417 |
45.2 |
No |
>9 |
| RHD-004 |
ENSP00000413849
ENST00000454452
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Q02161 Show all »
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Q02161 [Direct mapping]Blood group Rh(D) polypeptide Q5XLT3 [Target identity:100%; Query identity:100%]RHD protein; Rhesus blood group D antigen isoform 1 E7BAS5 [Target identity:95%; Query identity:100%]Rhesus blood group, D antigen B4F4S7 [Target identity:83%; Query identity:100%]Rhesus blood group, D antigen I2HA00 [Target identity:79%; Query identity:100%]Rhesus blood group D antigen B2ZGQ0 [Target identity:39%; Query identity:100%]Truncated Rhesus blood group D antigen D8MJ84 [Target identity:19%; Query identity:100%]Rh blood group D antigen P78522 [Target identity:19%; Query identity:100%]Rh blood group C antigen; Rh blood group D antigen; Rh blood group, CcEe antigens; Rh blood group, D antigen Q49IM6 [Target identity:17%; Query identity:100%]Rh blood group, D antigen; Rhesus blood group D antigen Q6A1H1 [Target identity:16%; Query identity:100%]Rhesus blood group D antigen A9P3T3 [Target identity:15%; Query identity:100%]Rh blood group RHD; RhD antigen; Rhesus blood group D antigen D2CRH1 [Target identity:15%; Query identity:100%]Rhesus blood group D antigen Q9UEC7 [Target identity:15%; Query identity:100%]RhC protein; RhD; Rhesus blood group D antigen A0PFK1 [Target identity:14%; Query identity:100%]Rhesus blood group C antigen I0CKG6 [Target identity:14%; Query identity:100%]Rh blood group D antigen Q5NDM5 [Target identity:14%; Query identity:100%]Rhesus blood group C antigen D8MJ86 [Target identity:11%; Query identity:100%]Truncated Rh blood group D antigen G0TQY3 [Target identity:11%; Query identity:100%]Rhesus blood group D antigen
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CD markers Blood group antigen proteins Transporters Transporter channels and pores Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 9TM proteins predicted by MDM Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level
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321 |
34.8 |
No |
9 |
| RHD-005 |
ENSP00000396420
ENST00000417538
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Q5XLT2 Show all »
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Q5XLT2 [Target identity:100%; Query identity:100%]Blood group Rh(D) polypeptide; Rhesus blood group D antigen isoform 2 E7BAS5 [Target identity:81%; Query identity:100%]Rhesus blood group, D antigen B4F4S7 [Target identity:70%; Query identity:100%]Rhesus blood group, D antigen I2HA00 [Target identity:67%; Query identity:100%]Rhesus blood group D antigen B2ZGQ0 [Target identity:33%; Query identity:100%]Truncated Rhesus blood group D antigen D8MJ84 [Target identity:16%; Query identity:100%]Rh blood group D antigen P78522 [Target identity:16%; Query identity:100%]Rh blood group C antigen; Rh blood group D antigen; Rh blood group, CcEe antigens; Rh blood group, D antigen Q49IM6 [Target identity:14%; Query identity:100%]Rh blood group, D antigen; Rhesus blood group D antigen Q6A1H1 [Target identity:14%; Query identity:100%]Rhesus blood group D antigen A9P3T3 [Target identity:13%; Query identity:100%]Rh blood group RHD; RhD antigen; Rhesus blood group D antigen A0PFK1 [Target identity:12%; Query identity:100%]Rhesus blood group C antigen D2CRH1 [Target identity:12%; Query identity:100%]Rhesus blood group D antigen I0CKG6 [Target identity:12%; Query identity:100%]Rh blood group D antigen Q9UEC7 [Target identity:12%; Query identity:100%]RhC protein; RhD; Rhesus blood group D antigen Q5NDM5 [Target identity:11%; Query identity:100%]Rhesus blood group C antigen D8MJ86 [Target identity:9%; Query identity:100%]Truncated Rh blood group D antigen G0TQY3 [Target identity:9%; Query identity:100%]Rhesus blood group D antigen
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Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 9TM proteins predicted by MDM
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378 |
41.7 |
No |
9 |
| RHD-006 |
ENSP00000350150
ENST00000357542
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Q02161 Show all »
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Q02161 [Direct mapping]Blood group Rh(D) polypeptide Q5XLT1 [Target identity:100%; Query identity:100%]Rhesus blood group D antigen isoform 3 I2HA01 [Target identity:86%; Query identity:100%]Rhesus blood group D antigen B4F4S0 [Target identity:80%; Query identity:100%]Rhesus blood group, D antigen E7BAS5 [Target identity:77%; Query identity:100%]Rhesus blood group, D antigen B4F4S7 [Target identity:67%; Query identity:100%]Rhesus blood group, D antigen I2HA00 [Target identity:64%; Query identity:100%]Rhesus blood group D antigen B2ZGQ0 [Target identity:32%; Query identity:100%]Truncated Rhesus blood group D antigen Q9UDZ3 [Target identity:31%; Query identity:100%]RHD protein D8MJ84 [Target identity:15%; Query identity:100%]Rh blood group D antigen P78522 [Target identity:15%; Query identity:100%]Rh blood group C antigen; Rh blood group D antigen; Rh blood group, CcEe antigens; Rh blood group, D antigen Q49IM6 [Target identity:13%; Query identity:100%]Rh blood group, D antigen; Rhesus blood group D antigen Q6A1H1 [Target identity:13%; Query identity:100%]Rhesus blood group D antigen A9P3T3 [Target identity:12%; Query identity:100%]Rh blood group RHD; RhD antigen; Rhesus blood group D antigen D2CRH1 [Target identity:12%; Query identity:100%]Rhesus blood group D antigen Q9UEC7 [Target identity:12%; Query identity:100%]RhC protein; RhD; Rhesus blood group D antigen A0PFK1 [Target identity:11%; Query identity:100%]Rhesus blood group C antigen A7Y8S3 [Target identity:11%; Query identity:100%]Rhesus blood group D antigen I0CKG6 [Target identity:11%; Query identity:100%]Rh blood group D antigen Q5NDM5 [Target identity:11%; Query identity:100%]Rhesus blood group C antigen D8MJ86 [Target identity:9%; Query identity:100%]Truncated Rh blood group D antigen G0TQY3 [Target identity:9%; Query identity:100%]Rhesus blood group D antigen
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CD markers Blood group antigen proteins Transporters Transporter channels and pores Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins >9TM proteins predicted by MDM Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level
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396 |
43.3 |
No |
>9 |
| RHD-007 |
ENSP00000456966
ENST00000568195
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H3BT10 Show all »
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H3BT10 [Target identity:100%; Query identity:100%]Blood group Rh(D) polypeptide I2HA01 [Target identity:73%; Query identity:100%]Rhesus blood group D antigen B4F4S0 [Target identity:68%; Query identity:100%]Rhesus blood group, D antigen E7BAS5 [Target identity:66%; Query identity:100%]Rhesus blood group, D antigen B4F4S7 [Target identity:57%; Query identity:100%]Rhesus blood group, D antigen I2HA00 [Target identity:55%; Query identity:100%]Rhesus blood group D antigen B2ZGQ0 [Target identity:27%; Query identity:100%]Truncated Rhesus blood group D antigen Q9UDZ3 [Target identity:26%; Query identity:100%]RHD protein D8MJ84 [Target identity:13%; Query identity:100%]Rh blood group D antigen P78522 [Target identity:13%; Query identity:100%]Rh blood group C antigen; Rh blood group D antigen; Rh blood group, CcEe antigens; Rh blood group, D antigen Q49IM6 [Target identity:11%; Query identity:100%]Rh blood group, D antigen; Rhesus blood group D antigen Q6A1H1 [Target identity:11%; Query identity:100%]Rhesus blood group D antigen A0PFK1 [Target identity:10%; Query identity:100%]Rhesus blood group C antigen A9P3T3 [Target identity:10%; Query identity:100%]Rh blood group RHD; RhD antigen; Rhesus blood group D antigen D2CRH1 [Target identity:10%; Query identity:100%]Rhesus blood group D antigen Q9UEC7 [Target identity:10%; Query identity:100%]RhC protein; RhD; Rhesus blood group D antigen A7Y8S3 [Target identity:9%; Query identity:100%]Rhesus blood group D antigen I0CKG6 [Target identity:9%; Query identity:100%]Rh blood group D antigen Q5NDM5 [Target identity:9%; Query identity:100%]Rhesus blood group C antigen D8MJ86 [Target identity:7%; Query identity:100%]Truncated Rh blood group D antigen G0TQY3 [Target identity:7%; Query identity:100%]Rhesus blood group D antigen
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Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins >9TM proteins predicted by MDM
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463 |
50.2 |
No |
>9 |
| RHD-008 |
ENSP00000339577
ENST00000342055
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Q5XLS9 Show all »
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Q5XLS9 [Target identity:100%; Query identity:100%]Blood group Rh(D) polypeptide; Rhesus blood group D antigen isoform 3 I2HA01 [Target identity:69%; Query identity:100%]Rhesus blood group D antigen B4F4S0 [Target identity:64%; Query identity:100%]Rhesus blood group, D antigen E7BAS5 [Target identity:62%; Query identity:100%]Rhesus blood group, D antigen B4F4S7 [Target identity:54%; Query identity:100%]Rhesus blood group, D antigen I2HA00 [Target identity:51%; Query identity:100%]Rhesus blood group D antigen B2ZGQ0 [Target identity:25%; Query identity:100%]Truncated Rhesus blood group D antigen Q9UDZ3 [Target identity:25%; Query identity:100%]RHD protein D8MJ84 [Target identity:12%; Query identity:100%]Rh blood group D antigen P78522 [Target identity:12%; Query identity:100%]Rh blood group C antigen; Rh blood group D antigen; Rh blood group, CcEe antigens; Rh blood group, D antigen Q49IM6 [Target identity:11%; Query identity:100%]Rh blood group, D antigen; Rhesus blood group D antigen A9P3T3 [Target identity:10%; Query identity:100%]Rh blood group RHD; RhD antigen; Rhesus blood group D antigen Q6A1H1 [Target identity:10%; Query identity:100%]Rhesus blood group D antigen A0PFK1 [Target identity:9%; Query identity:100%]Rhesus blood group C antigen D2CRH1 [Target identity:9%; Query identity:100%]Rhesus blood group D antigen I0CKG6 [Target identity:9%; Query identity:100%]Rh blood group D antigen Q5NDM5 [Target identity:9%; Query identity:100%]Rhesus blood group C antigen Q9UEC7 [Target identity:9%; Query identity:100%]RhC protein; RhD; Rhesus blood group D antigen A7Y8S3 [Target identity:8%; Query identity:100%]Rhesus blood group D antigen D8MJ86 [Target identity:7%; Query identity:100%]Truncated Rh blood group D antigen G0TQY3 [Target identity:7%; Query identity:100%]Rhesus blood group D antigen
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Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins >9TM proteins predicted by MDM
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493 |
53.6 |
No |
>9 |
| RHD-009 |
ENSP00000399640
ENST00000423810
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E7EVW1 Show all »
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E7EVW1 [Target identity:100%; Query identity:100%]Blood group Rh(D) polypeptide I2HA01 [Target identity:79%; Query identity:100%]Rhesus blood group D antigen B4F4S0 [Target identity:73%; Query identity:100%]Rhesus blood group, D antigen E7BAS5 [Target identity:71%; Query identity:100%]Rhesus blood group, D antigen B4F4S7 [Target identity:62%; Query identity:100%]Rhesus blood group, D antigen I2HA00 [Target identity:59%; Query identity:100%]Rhesus blood group D antigen B2ZGQ0 [Target identity:29%; Query identity:100%]Truncated Rhesus blood group D antigen Q9UDZ3 [Target identity:28%; Query identity:100%]RHD protein D8MJ84 [Target identity:14%; Query identity:100%]Rh blood group D antigen P78522 [Target identity:14%; Query identity:100%]Rh blood group C antigen; Rh blood group D antigen; Rh blood group, CcEe antigens; Rh blood group, D antigen Q49IM6 [Target identity:12%; Query identity:100%]Rh blood group, D antigen; Rhesus blood group D antigen Q6A1H1 [Target identity:12%; Query identity:100%]Rhesus blood group D antigen A9P3T3 [Target identity:11%; Query identity:100%]Rh blood group RHD; RhD antigen; Rhesus blood group D antigen D2CRH1 [Target identity:11%; Query identity:100%]Rhesus blood group D antigen Q9UEC7 [Target identity:11%; Query identity:100%]RhC protein; RhD; Rhesus blood group D antigen A0PFK1 [Target identity:10%; Query identity:100%]Rhesus blood group C antigen A7Y8S3 [Target identity:10%; Query identity:100%]Rhesus blood group D antigen I0CKG6 [Target identity:10%; Query identity:100%]Rh blood group D antigen Q5NDM5 [Target identity:10%; Query identity:100%]Rhesus blood group C antigen D8MJ86 [Target identity:8%; Query identity:100%]Truncated Rh blood group D antigen G0TQY3 [Target identity:8%; Query identity:100%]Rhesus blood group D antigen
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Potential transmembrane proteins Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins >9TM proteins predicted by MDM
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431 |
46.3 |
No |
>9 |
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