AKR1C1

GENE INFORMATION

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Gene name

AKR1C1 (HGNC Symbol)

Synonyms

DD1, DDH, DDH1, HAKRC, MBAB

Description

aldo-keto reductase family 1, member C1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]

Chromosome

10 (Chromosome progress)

Cytoband

p15.1

Chromosome location (bp)

4934796 - 5025475

Ensembl

ENSG00000187134 (version 73.37)

Entrez gene

1645

UniProt

Q04828 (UniProt - Evidence at protein level)

neXtProt

NX_Q04828

Antibodypedia

AKR1C1 antibodies
 

PROTEIN VIEW

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AKR1C1-001
 
AKR1C1-003
 
AKR1C1-004
 
AKR1C1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AKR1C1-001 ENSP00000370254
ENST00000380872
Q04828
Show all »
Show » Show » 323 36.8 No 0
AKR1C1-003 ENSP00000416415
ENST00000442997
248 28.1 No 0
AKR1C1-004 ENSP00000370240
ENST00000380859
A6NHU4
Show all »
Show » 205 23.2 Yes 0
AKR1C1-201 ENSP00000412248
ENST00000434459
Q04828
Show all »
Show » Show » 323 36.8 No 0