BCAM

GENE INFORMATION

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Gene name

BCAM (HGNC Symbol)

Synonyms

CD239, LU

Description

basal cell adhesion molecule (Lutheran blood group) (HGNC Symbol)

Entrez gene summary

This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Chromosome

19 (Chromosome progress)

Cytoband

q13.32

Chromosome location (bp)

45312328 - 45324673

Ensembl

ENSG00000187244 (version 73.37)

Entrez gene

4059

UniProt

P50895 (UniProt - Evidence at protein level)

neXtProt

NX_P50895

Antibodypedia

BCAM antibodies
 

PROTEIN VIEW

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BCAM-001
 
BCAM-005
 
BCAM-006
 
BCAM-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BCAM-001 ENSP00000270233
ENST00000270233
P50895
Show all »
Show » Show » 628 67.4 Yes 1
BCAM-005 ENSP00000468189
ENST00000590196
61 6.8 No 0
BCAM-006 ENSP00000467100
ENST00000591520
K7ENU8
Show all »
Show » 291 32.1 Yes 0
BCAM-201 ENSP00000375817
ENST00000391955
P50895
Show all »
Show » Show » 588 63.7 Yes 1