EPOR

GENE INFORMATION

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Gene name

EPOR

Synonyms

Description

erythropoietin receptor (HGNC Symbol)

Entrez gene summary

This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Chromosome

19 (Chromosome progress)

Cytoband

p13.2

Chromosome location (bp)

11488236 - 11495018

Ensembl

ENSG00000187266 (version 73.37)

Entrez gene

2057

UniProt

P19235 (UniProt - Evidence at protein level)

neXtProt

NX_P19235

Antibodypedia

EPOR antibodies
 

PROTEIN VIEW

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EPOR-001
 
EPOR-002
 
EPOR-003
 
EPOR-004
 
EPOR-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EPOR-001 ENSP00000222139
ENST00000222139
P19235
Show all »
Show » Show » 508 55.1 Yes 1
EPOR-002 ENSP00000466784
ENST00000588859
K7EN47
Show all »
Show » 119 12.5 Yes 0
EPOR-003 ENSP00000468187
ENST00000591958
K7ERB5
Show all »
Show » Show » 276 29.9 Yes 0
EPOR-004 ENSP00000467230
ENST00000586890
K7EP50
Show all »
Show » 130 13.8 Yes 0
EPOR-005 ENSP00000467809
ENST00000592375
Show » Show » 328 35.8 Yes 1