DPYD

GENE INFORMATION

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Gene name

DPYD (HGNC Symbol)

Synonyms

DPD

Description

Dihydropyrimidine dehydrogenase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Chromosome

1

Cytoband

p21.3

Chromosome location (bp)

97543299 - 98386605

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000188641 (version 75.37)

Entrez gene

1806

UniProt

Q12882 (UniProt - Evidence at protein level)

neXtProt

NX_Q12882

Antibodypedia

DPYD antibodies
 

PROTEIN VIEW

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DPYD-001
 
DPYD-002
 
DPYD-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DPYD-001 ENSP00000359211
ENST00000370192
Q12882
Show all »
Show » Show » 1025 111.5 No 0
DPYD-002 ENSP00000307107
ENST00000306031
Show » Show » 173 19 No 0
DPYD-201 ENSP00000398884
ENST00000423006
B4DML1
Show all »
Show » Show » 156 16.9 No 0