LRRK2

GENE INFORMATION

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Gene name

LRRK2 (HGNC Symbol)

Synonyms

DKFZp434H2111, FLJ45829, PARK8, RIPK7, ROCO2

Description

leucine-rich repeat kinase 2 (HGNC Symbol)

Entrez gene summary

This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]

Chromosome

12 (Chromosome progress)

Cytoband

q12

Chromosome location (bp)

40590546 - 40763087

Ensembl

ENSG00000188906 (version 73.37)

Entrez gene

120892

UniProt

Q5S007 (UniProt - Evidence at protein level)

neXtProt

NX_Q5S007

Antibodypedia

LRRK2 antibodies
 

PROTEIN VIEW

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LRRK2-001
 
LRRK2-002
 
LRRK2-004
 
LRRK2-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LRRK2-001 ENSP00000398726
ENST00000416796
C9JBF0
Show all »
Show » 521 58.2 No 0
LRRK2-002 ENSP00000341930
ENST00000343742
E9PC85
Show all »
Show » Show » 1271 143.1 No 0
LRRK2-004 ENSP00000298910
ENST00000298910
Q5S007
Show all »
Show » Show » 2527 286.1 No 0
LRRK2-005 ENSP00000410821
ENST00000430804
Show » 207 22.9 No 0