PAX5

GENE INFORMATION

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Gene name

PAX5 (HGNC Symbol)

Synonyms

BSAP

Description

paired box 5 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

Chromosome

9 (Chromosome progress)

Cytoband

p13.2

Chromosome location (bp)

36833272 - 37034103

Ensembl

ENSG00000196092 (version 73.37)

Entrez gene

5079

UniProt

Q02548 (UniProt - Evidence at protein level)

neXtProt

NX_Q02548

Antibodypedia

PAX5 antibodies
 

PROTEIN VIEW

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PAX5-001
 
PAX5-002
 
PAX5-003
 
PAX5-004
 
PAX5-005
 
PAX5-006
 
PAX5-007
 
PAX5-008
 
PAX5-009
 
PAX5-010
 
PAX5-011
 
PAX5-012
 
PAX5-013
 
PAX5-014
 
PAX5-015
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PAX5-001 ENSP00000350844
ENST00000358127
Q02548
Show all »
Show » Show » 391 42.1 No 0
PAX5-002 ENSP00000367071
ENST00000377840
Q02548
Show all »
Show » Show » 288 31.8 No 0
PAX5-003 ENSP00000367083
ENST00000377852
Q02548
Show all »
Show » Show » 357 38.8 No 0
PAX5-004 ENSP00000367084
ENST00000377853
Q02548
Show all »
Show » Show » 362 38.9 No 0
PAX5-005 ENSP00000430773
ENST00000520281
C0KTF8
Show all »
Show » Show » 319 34.6 No 0
PAX5-006 ENSP00000429637
ENST00000523241
E7EQT0
Show all »
Show » Show » 324 35.3 No 0
PAX5-007 ENSP00000429291
ENST00000520154
E7ERW5
Show all »
Show » Show » 295 32.5 No 0
PAX5-008 ENSP00000404687
ENST00000446742
C0KTF9
Show all »
Show » Show » 291 31.4 No 0
PAX5-009 ENSP00000429359
ENST00000522003
E7ERK2
Show all »
Show » Show » 283 30.3 No 0
PAX5-010 ENSP00000429197
ENST00000523145
E7ES87
Show all »
Show » Show » 220 23.7 No 0
PAX5-011 ENSP00000431038
ENST00000523493
C0KTG0
Show all »
Show » Show » 307 34.1 No 0
PAX5-012 ENSP00000367078
ENST00000377847
C0KTF6
Show all »
Show » Show » 328 35.5 No 0
PAX5-013 ENSP00000412188
ENST00000414447
C0KTF7
Show all »
Show » Show » 348 37.8 No 0
PAX5-014 ENSP00000429404
ENST00000524340
C0KTE2
Show all »
Show » 218 23.8 No 0
PAX5-015 ENSP00000428670
ENST00000522932
C0KTE9
Show all »
Show » 60 6 No 0