HLA-DRB1

CANCER ATLAS

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Gene description

Major histocompatibility complex, class II, DR beta 1

Protein class

Disease related genes, Plasma proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level
 
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY

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HPA043151
 
CAB015400
 
CAB034021
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 
 

Staining summary

Several cases of malignant lymphomas, cervical, endometrial and head & neck cancers along with a few cases of malignant melanomas, colorectal, ovarian and gastric cancers exhibited moderate cytoplasmic and occasional membranous positivity. Strong staining was observed in a few lung and endometrial cancers. Inflammatory cells in the stroma were distinctly stained. Remaining malignant cells were mainly negative.
 

Level of antibody staining/expression





High
Medium
Low
Not detected