HLA-DRB1

GENERAL INFORMATION

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Gene name

HLA-DRB1

Gene description

Major histocompatibility complex, class II, DR beta 1

Protein class

Disease related genes
Plasma proteins
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Selective membranous and cytoplasmic expression in lymphoid cells.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation. Caution, targets protein from more than one gene.

Data reliability

Supportive based on 3 antibodies.
HPA043151 , CAB015400 , CAB034021
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Lung

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

HLA-DRB1 (HGNC Symbol)

Synonyms

HLA-DR1B

Description

Major histocompatibility complex, class II, DR beta 1 (HGNC Symbol)

Entrez gene summary

HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p21.32

Chromosome location (bp)

32552990 - 32589848

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000196126 (version 78.38)

Entrez gene

3123

UniProt

P01911 (UniProt - Evidence at protein level), P04229 (UniProt - Evidence at protein level), Q29974 (UniProt - Evidence at protein level), Q9GIY3 (UniProt - Evidence at protein level)

neXtProt

NX_P01911, NX_P04229, NX_Q29974, NX_Q9GIY3

Antibodypedia

HLA-DRB1 antibodies


PROTEIN BROWSER

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ENST00000360004
 
ENST00000611060
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HLA-DRB1-001 ENSP00000353099
ENST00000360004
P01911
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Show » Show » 266 30 Yes 1
HLA-DRB1-201 ENSP00000480667
ENST00000611060
A0N0W0
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Show » Show » 266 29.9 Yes 1