The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
Most malignant lymphomas showed moderate to strong cytoplasmic and membranous staining. Most other malignant cells were negative.
Several non-Hodgkins lymphomas and fractions of cases in squamous cell carcinomas, ductal breas cancers and female genital cancers exhibited moderate to strong cytoplasmic immunoreactivity. Remaining tumors were negative.
Several cases of malignant lymphomas, cervical, endometrial and head & neck cancers along with a few cases of malignant melanomas, colorectal, ovarian and gastric cancers exhibited moderate cytoplasmic and occasional membranous positivity. Strong staining was observed in a few lung and endometrial cancers. Inflammatory cells in the stroma were distinctly stained. Remaining malignant cells were mainly negative.
Validation
Two (or more) antibodies yielding similar staining patterns which are consistent with available gene/protein characterization data
Two (or more) antibodies yielding similar staining patterns which are consistent with available gene/protein characterization data
The multi-targeting antibody yielding a staining pattern consistent with gene/protein characterization data for all of the genes
