HLA-DRB1

GENE INFORMATION

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Gene name

HLA-DRB1 (HGNC Symbol)

Synonyms

HLA-DR1B

Description

major histocompatibility complex, class II, DR beta 1 (HGNC Symbol)

Entrez gene summary

HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]

Chromosome

6 (Chromosome progress)

Cytoband

p21.32

Chromosome location (bp)

32546546 - 32557625

Ensembl

ENSG00000196126 (version 73.37)

Entrez gene

3123

UniProt

P01911 (UniProt - Evidence at protein level), P04229 (UniProt - Evidence at protein level), Q29974 (UniProt - Evidence at protein level), Q9GIY3 (UniProt - Evidence at protein level)

neXtProt

NX_P01911, NX_P04229, NX_Q29974, NX_Q9GIY3

Antibodypedia

HLA-DRB1 antibodies
 

PROTEIN VIEW

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HLA-DRB1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HLA-DRB1-001 ENSP00000353099
ENST00000360004
P01911
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