The gene information section lists the gene name (HUGO Gene Nomenclature Committee (HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version. The Entrez gene identifier for the gene is also given. If any of the protein products of the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the neXtProt databases for these proteins are displayed.
Gene name
HLA-DRB1 (HGNC Symbol)
Synonyms
HLA-DR1B
Description
major histocompatibility complex, class II, DR beta 1 (HGNC Symbol)
Entrez gene summary
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]
The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Common (purple) and unique (grey) regions between alternative processed transcripts from the same gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website for that protein, and the ENST identifier links to the Ensembl website for that transcript. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues) (according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius and predicted transmembrane region(s) (according to MDM) are also reported.
P01911 [Direct mapping] HLA class II histocompatibility antigen, DRB1-15 beta chain P04229 [Direct mapping] HLA class II histocompatibility antigen, DRB1-1 beta chain Q29974 [Direct mapping] HLA class II histocompatibility antigen, DRB1-16 beta chain Q9GIY3 [Direct mapping] HLA class II histocompatibility antigen, DRB1-14 beta chain D7RIH8 [Target identity:100%; Query identity:100%] MHC class II antigen F2QL89 [Target identity:68%; Query identity:100%] MHC class II antigen A0N0W0 [Target identity:33%; Query identity:100%] MHC class II antigen A1Z0K9 [Target identity:33%; Query identity:100%] MHC class II antigen C8CJD1 [Target identity:33%; Query identity:100%] MHC class II antigen D3U4F4 [Target identity:33%; Query identity:100%] MHC class II antigen D5FIC8 [Target identity:33%; Query identity:100%] MHC class II antigen D5FIC9 [Target identity:33%; Query identity:100%] MHC class II antigen D5FID0 [Target identity:33%; Query identity:100%] MHC class II antigen D5FID2 [Target identity:33%; Query identity:100%] MHC class II antigen D5FID6 [Target identity:33%; Query identity:100%] MHC class II antigen D5FID7 [Target identity:33%; Query identity:100%] MHC class II antigen D5FID8 [Target identity:33%; Query identity:100%] MHC class II antigen D5FID9 [Target identity:33%; Query identity:100%] MHC class II antigen D5FIE4 [Target identity:33%; Query identity:100%] MHC class II antigen D5FIE6 [Target identity:33%; Query identity:100%] MHC class II antigen D5FIE7 [Target identity:33%; Query identity:100%] MHC class II antigen D5FIE8 [Target identity:33%; Query identity:100%] MHC class II antigen D5FIE9 [Target identity:33%; Query identity:100%] MHC class II antigen D5FIF2 [Target identity:33%; Query identity:100%] MHC class II antigen D5FZP4 [Target identity:33%; Query identity:100%] MHC class II antigen D5FZP5 [Target identity:33%; Query identity:100%] MHC class II antigen D5G2K8 [Target identity:33%; Query identity:100%] MHC class II antigen D5M899 [Target identity:33%; Query identity:100%] MHC class II antigen D5M8A0 [Target identity:33%; Query identity:100%] MHC class II antigen D6BPR2 [Target identity:33%; Query identity:100%] MHC class II antigen D6MJC0 [Target identity:33%; Query identity:100%] MHC class II antigen D6MJL2 [Target identity:33%; Query identity:100%] MHC class II antigen D7NR21 [Target identity:33%; Query identity:100%] MHC class II antigen D9IFQ2 [Target identity:33%; Query identity:100%] MHC class II antigen E0X9M7 [Target identity:33%; Query identity:100%] MHC class II antigen E3SWN8 [Target identity:33%; Query identity:100%] MHC class II antigen E3SWN9 [Target identity:33%; Query identity:100%] MHC class II antigen E3SWP0 [Target identity:33%; Query identity:100%] MHC class II antigen E7BYD5 [Target identity:33%; Query identity:100%] MHC class II antigen F0V6B9 [Target identity:33%; Query identity:100%] MHC class II antigen F1CCL9 [Target identity:33%; Query identity:100%] MHC class II antigen F1CCN2 [Target identity:33%; Query identity:100%] MHC class II antigen F1CCN5 [Target identity:33%; Query identity:100%] MHC class II antigen F1CCP7 [Target identity:33%; Query identity:100%] MHC class II antigen F2VNV5 [Target identity:33%; Query identity:100%] MHC class II antigen F2VNV6 [Target identity:33%; Query identity:100%] MHC class II antigen F2VNW9 [Target identity:33%; Query identity:100%] MHC class II antigen F2X654 [Target identity:33%; Query identity:100%] MHC class II antigen F4YUA8 [Target identity:33%; Query identity:100%] MHC class II antigen F4YZW3 [Target identity:33%; Query identity:100%] MHC class II antigen F4YZX1 [Target identity:33%; Query identity:100%] MHC class II antigen F4YZX2 [Target identity:33%; Query identity:100%] MHC class II antigen F4YZX3 [Target identity:33%; Query identity:100%] MHC class II antigen F4YZX4 [Target identity:33%; Query identity:100%] MHC class II antigen F4YZX5 [Target identity:33%; Query identity:100%] MHC class II antigen F8R8N0 [Target identity:33%; Query identity:100%] MHC class II antigen F8R8N1 [Target identity:33%; Query identity:100%] MHC class II antigen G0ZDX1 [Target identity:33%; Query identity:100%] MHC class II antigen G0ZMM8 [Target identity:33%; Query identity:100%] MHC class II antigen G0ZMM9 [Target identity:33%; Query identity:100%] MHC class II antigen G1CD91 [Target identity:33%; Query identity:100%] MHC class II antigen G1EMX4 [Target identity:33%; Query identity:100%] MHC class II antigen G1EMX6 [Target identity:33%; Query identity:100%] MHC class II antigen G9HW13 [Target identity:33%; Query identity:100%] MHC class II antigen G9I2P4 [Target identity:33%; Query identity:100%] MHC Class II antigen H2BDR9 [Target identity:33%; Query identity:100%] MHC class II antigen H6A2E5 [Target identity:33%; Query identity:100%] MHC class II antigen H8WV95 [Target identity:33%; Query identity:100%] MHC class II antigen Q1G0Z8 [Target identity:33%; Query identity:100%] MHC class II antigen Q1G100 [Target identity:33%; Query identity:100%] MHC class II antigen Q860S9 [Target identity:33%; Query identity:100%] MHC class II antigen Q8MGY6 [Target identity:33%; Query identity:100%] MHC class II antigen Q95HN3 [Target identity:33%; Query identity:100%] MHC class II antigen Q9MYD9 [Target identity:33%; Query identity:100%] MHC class II antigen Q9TQ40 [Target identity:33%; Query identity:100%] MHC class II antigen B7VU65 [Target identity:31%; Query identity:100%] MHC class II antigen Q8WMA1 [Target identity:29%; Query identity:100%] MHC class II antigen Q8HWN3 [Target identity:28%; Query identity:100%] MHC class II antigen Q3LTJ8 [Target identity:27%; Query identity:100%] MHC class II antigen Q5Y7C5 [Target identity:12%; Query identity:100%] MHC class II antigen Q06653 [Target identity:10%; Query identity:100%] MHC class II antigen
