The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
Most breast cancers showed moderate cytoplasmic positivity with a granular pattern. Other malignancies were generally negative.
Most malignant tissues displayed moderate to strong cytoplasmic and extracellular positivity. Several cases of malignant lymphomas, squamous cell carcinomas, prostate- and colorectal cancers were negative.
Most malignant tissues were weakly stained or negative. Cases of endometrial cancers exhibited strong cytoplasmic immunoreactivity along with distinct positivity in extracellular material. Most cases of breast and some cases of prostate, ovarian and pancreatic cancers revealed moderate cytoplasmic staining. Some gliomas showed moderate nuclear and/or cytoplasmic staining.
Validation
Two (or more) antibodies yielding partly similar staining patterns which are consistent with gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are consistent with gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are consistent with gene/protein characterization data
