AKR1C3

GENE INFORMATION

? »

Gene name

AKR1C3 (HGNC Symbol)

Synonyms

DDX, HAKRB, HSD17B5, KIAA0119, PGFS

Description

aldo-keto reductase family 1, member C3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Chromosome

10 (Chromosome progress)

Cytoband

p15.1

Chromosome location (bp)

5077546 - 5149878

Ensembl

ENSG00000196139 (version 73.37)

Entrez gene

8644

UniProt

P42330 (UniProt - Evidence at protein level)

neXtProt

NX_P42330

Antibodypedia

AKR1C3 antibodies
 

PROTEIN VIEW

? »
 
 
 
AKR1C3-001
 
AKR1C3-006
 
AKR1C3-008
 
AKR1C3-201
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AKR1C3-001 ENSP00000369927
ENST00000380554
P42330
Show all »
Show » Show » 323 36.9 No 0
AKR1C3-006 ENSP00000474882
ENST00000605149
B4DL37
Show all »
Show » 300 34.3 No 0
AKR1C3-008 ENSP00000474188
ENST00000602997
155 17.6 No 0
AKR1C3-201 ENSP00000401327
ENST00000439082
B4DL37
Show all »
Show » 204 23.4 No 0