CTSE

GENE INFORMATION

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Gene name

CTSE

Synonyms

Description

cathepsin E (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease, which is a member of the peptidase C1 family, has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach. It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric cancers. It appears, therefore, to be an oncofetal antigen. Transcript variants utilizing alternative polyadenylation signals and two transcript variants encoding different isoforms exist for this gene. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

q32.1

Chromosome location (bp)

206317459 - 206332104

Ensembl

ENSG00000196188 (version 73.37)

Entrez gene

1510

UniProt

P14091 (UniProt - Evidence at protein level)

neXtProt

NX_P14091

Antibodypedia

CTSE antibodies
 

PROTEIN VIEW

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CTSE-001
 
CTSE-002
 
CTSE-201
 
CTSE-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CTSE-001 ENSP00000350911
ENST00000358184
P14091
Show all »
Show » Show » 396 42.8 Yes 0
CTSE-002 ENSP00000353350
ENST00000360218
P14091
Show all »
Show » Show » 363 39.6 Yes 0
CTSE-201 ENSP00000354337
ENST00000361052
J3KP48
Show all »
Show » Show » 401 43.4 Yes 0
CTSE-202 ENSP00000394607
ENST00000432969
B4DNU8
Show all »
Show » 288 30.9 No 0