GRM7

GENERAL INFORMATION

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Gene name

GRM7

Gene description

Glutamate receptor, metabotropic 7

Protein class

G-protein coupled receptors
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (cerebral cortex, smooth muscle)
GTEx:Tissue enhanced (cerebral cortex, hippocampus)

Protein evidence

Evidence at protein level

Protein localization

Strong cytoplasmic positivity was observed in lung macrophages, intestinal tract, gall bladder, renal tubules and Leydig cells. Stomach, hepotocytes, endocrine glands and myocytes showed moderate staining. Remaining normal tissues were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA036659
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (cerebral cortex, smooth muscle)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (cerebral cortex, hippocampus)

Organ

Expression



GENE INFORMATION

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Gene name

GRM7 (HGNC Symbol)

Synonyms

GLUR7, GPRC1G, mGlu7, MGLUR7, PPP1R87

Description

Glutamate receptor, metabotropic 7 (HGNC Symbol)

Entrez gene summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

Chromosome

3

Cytoband

p26.1

Chromosome location (bp)

6770001 - 7741533

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000196277 (version 78.38)

Entrez gene

2917

UniProt

Q14831 (UniProt - Evidence at protein level)

neXtProt

NX_Q14831

Antibodypedia

GRM7 antibodies


PROTEIN BROWSER

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ENST00000357716
 
ENST00000389336
 
ENST00000402647
 
ENST00000445087
 
ENST00000448328
 
ENST00000486284
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GRM7-001 ENSP00000350348
ENST00000357716
Q14831
Show all »
Show » Show » 915 102.3 Yes 7
GRM7-003 ENSP00000373987
ENST00000389336
Q14831
Show all »
Show » Show » 906 101.3 Yes 7
GRM7-009 ENSP00000395035
ENST00000445087
C9JMT3
Show all »
Show » Show » 185 21.2 No 0
GRM7-012 ENSP00000393799
ENST00000448328
C9JU97
Show all »
Show » Show » 122 13.5 No 0
GRM7-015 ENSP00000417536
ENST00000486284
Q14831
Show all »
Show » Show » 922 103.1 Yes 7
GRM7-201 ENSP00000384585
ENST00000402647
C9JU97
Show all »
Show » Show » 714 80.4 No 7