ATP2A1

GENE INFORMATION

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Gene name

ATP2A1 (HGNC Symbol)

Synonyms

ATP2A, SERCA1

Description

ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 (HGNC Symbol)

Entrez gene summary

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

16 (Chromosome progress)

Cytoband

p11.2

Chromosome location (bp)

28889726 - 28915830

Ensembl

ENSG00000196296 (version 73.37)

Entrez gene

487

UniProt

O14983 (UniProt - Evidence at protein level)

neXtProt

NX_O14983

Antibodypedia

ATP2A1 antibodies
 

PROTEIN VIEW

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ATP2A1-001
 
ATP2A1-002
 
ATP2A1-003
 
ATP2A1-005
 
ATP2A1-007
 
ATP2A1-008
 
ATP2A1-009
 
ATP2A1-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP2A1-001 ENSP00000349595
ENST00000357084
O14983
Show all »
Show » Show » 1001 110.3 No >9
ATP2A1-002 ENSP00000378879
ENST00000395503
O14983
Show all »
Show » Show » 994 109.3 No >9
ATP2A1-003 ENSP00000443101
ENST00000536376
B3KY17
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Show » Show » 869 95.2 No 8
ATP2A1-005 ENSP00000457148
ENST00000564470
H3BTF1
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41 4.4 No 0
ATP2A1-007 ENSP00000458035
ENST00000563975
H3BVB2
Show all »
Show » Show » 114 13.1 No 2
ATP2A1-008 ENSP00000457798
ENST00000562185
H3BUU3
Show all »
Show » 26 3 No 0
ATP2A1-009 ENSP00000457357
ENST00000564732
Show » Show » 128 13.8 No 1
ATP2A1-010 ENSP00000457793
ENST00000564112
24 2.6 No 0