IARS

GENE INFORMATION

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Gene name

IARS (HGNC Symbol)

Synonyms

IARS1, ILRS

Description

isoleucyl-tRNA synthetase (HGNC Symbol)

Entrez gene summary

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2012]

Chromosome

9 (Chromosome progress)

Cytoband

q22.31

Chromosome location (bp)

94972489 - 95056038

Ensembl

ENSG00000196305 (version 73.37)

Entrez gene

3376

UniProt

P41252 (UniProt - Evidence at protein level)

neXtProt

NX_P41252

Antibodypedia

IARS antibodies
 

PROTEIN VIEW

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IARS-001
 
IARS-002
 
IARS-006
 
IARS-010
 
IARS-201
 
IARS-202
 
IARS-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IARS-001 ENSP00000364794
ENST00000375643
P41252
Show all »
Show » Show » 1262 144.5 No 0
IARS-002 ENSP00000378922
ENST00000395554
Q5TCD1
Show all »
Show » 330 38.3 No 0
IARS-006 ENSP00000387603
ENST00000430417
Q5TCC9
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72 8.8 No 0
IARS-010 ENSP00000364778
ENST00000375627
Q5TCC6
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174 19.5 No 0
IARS-201 ENSP00000364780
ENST00000375629
Q5TCC6
Show all »
174 19.5 No 0
IARS-202 ENSP00000406448
ENST00000443024
P41252
Show all »
Show » Show » 1262 144.5 No 0
IARS-203 ENSP00000415020
ENST00000447699
J3KR24
Show all »
Show » Show » 1152 131.8 No 0