LONP1

GENE INFORMATION

? »

Gene name

LONP1 (HGNC Symbol)

Synonyms

hLON, LonHS, PIM1, PRSS15

Description

Lon peptidase 1, mitochondrial (HGNC Symbol)

Entrez gene summary

This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013]

Chromosome

19

Cytoband

p13.3

Chromosome location (bp)

5691845 - 5720583

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000196365 (version 75.37)

Entrez gene

9361

UniProt

P36776 (UniProt - Evidence at protein level)

neXtProt

NX_P36776

Antibodypedia

LONP1 antibodies
 

PROTEIN VIEW

? »
 
 
 
LONP1-001
 
LONP1-002
 
LONP1-003
 
LONP1-005
 
LONP1-007
 
LONP1-009
 
LONP1-014
 
LONP1-015
 
LONP1-016
 
LONP1-017
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LONP1-001 ENSP00000353826
ENST00000360614
P36776
Show all »
Show » Show » 959 106.5 No 0
LONP1-002 ENSP00000441523
ENST00000540670
F5GZ27
Show all »
Show » Show » 763 85.6 No 0
LONP1-003 ENSP00000465585
ENST00000585374
K7EKE6
Show all »
Show » Show » 845 95.2 No 0
LONP1-005 ENSP00000468541
ENST00000593119
Q8N8K8
Show all »
Show » Show » 895 100.4 No 0
LONP1-007 ENSP00000465139
ENST00000590729
K7EJE8
Show all »
Show » Show » 829 93.3 No 0
LONP1-009 ENSP00000468385
ENST00000586617
K7ERS1
Show all »
Show » 86 9.1 No 0
LONP1-014 ENSP00000468083
ENST00000590206
Show » Show » 242 27.5 No 0
LONP1-015 ENSP00000468114
ENST00000587365
K7ER56
Show all »
Show » Show » 210 22.6 No 0
LONP1-016 ENSP00000468379
ENST00000589473
K7ERR6
Show all »
Show » Show » 264 27.8 No 0
LONP1-017 ENSP00000467808
ENST00000590558
K7EQF8
Show all »
Show » Show » 185 20.3 No 0