PTPN1

GENE INFORMATION

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Gene name

PTPN1 (HGNC Symbol)

Synonyms

PTP1B

Description

protein tyrosine phosphatase, non-receptor type 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

Chromosome

20 (Chromosome progress)

Cytoband

q13.13

Chromosome location (bp)

49126891 - 49201299

Ensembl

ENSG00000196396 (version 73.37)

Entrez gene

5770

UniProt

P18031 (UniProt - Evidence at protein level)

neXtProt

NX_P18031

Antibodypedia

PTPN1 antibodies
 

PROTEIN VIEW

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PTPN1-001
 
PTPN1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTPN1-001 ENSP00000360683
ENST00000371621
P18031
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Show » Show » 435 50 No 1
PTPN1-201 ENSP00000437732
ENST00000541713
B4DSN5
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Show » Show » 362 41.3 No 1