EPHB4

GENE INFORMATION

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Gene name

EPHB4 (HGNC Symbol)

Synonyms

HTK, Tyro11

Description

EPH receptor B4 (HGNC Symbol)

Entrez gene summary

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

q22.1

Chromosome location (bp)

100400187 - 100425121

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000196411 (version 75.37)

Entrez gene

2050

UniProt

P54760 (UniProt - Evidence at protein level)

neXtProt

NX_P54760

Antibodypedia

EPHB4 antibodies
 

PROTEIN VIEW

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EPHB4-001
 
EPHB4-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EPHB4-001 ENSP00000350896
ENST00000358173
P54760
Show all »
Show » Show » 987 108.3 Yes 1
EPHB4-005 ENSP00000353833
ENST00000360620
Q96L35
Show all »
Show » Show » 935 102.6 Yes 1