AFAP1

GENERAL INFORMATION

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Gene name

AFAP1

Gene description

Actin filament associated protein 1

Protein class

Cytoskeleton related proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression which a granular pattern in several tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 2 antibodies.
HPA015642 , CAB024712
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

AFAP1 (HGNC Symbol)

Synonyms

AFAP, AFAP-110

Description

Actin filament associated protein 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Chromosome

4

Cytoband

p16.1

Chromosome location (bp)

7758714 - 7939926

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000196526 (version 78.38)

Entrez gene

60312

UniProt

Q8N556 (UniProt - Evidence at protein level)

neXtProt

NX_Q8N556

Antibodypedia

AFAP1 antibodies


PROTEIN BROWSER

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ENST00000358461
 
ENST00000360265
 
ENST00000382543
 
ENST00000420658
 
ENST00000614385
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AFAP1-001 ENSP00000353402
ENST00000360265
Q8N556
Show all »
Show » Show » 730 80.7 No 0
AFAP1-002 ENSP00000371983
ENST00000382543
Q8N556
Show all »
Show » Show » 814 89.8 No 0
AFAP1-008 ENSP00000483962
ENST00000614385
Show » 92 9.7 No 0
AFAP1-201 ENSP00000351245
ENST00000358461
Q8N556
Show all »
Show » Show » 730 80.7 No 0
AFAP1-202 ENSP00000410689
ENST00000420658
Q8N556
Show all »
Show » Show » 814 89.8 No 0